个人简介：

查高峰，中山大学附属第七医院副研究员，中山大学“百人计划”青年骨干引进人才，Karolinska Institutet博士后。近五年以第一作者或通讯作者在权威期刊上发表SCI论文18篇，包括J. Am. Chem. Soc.; Angew. Chem. Int. Ed.; Org. Lett.；Eur. J. Med. Chem.; Adv. Synth. Catal.; Chem. Commun.等，其中2篇论文入选ESI高被引论文 (top 1%)，H-Index 15。申请专利10余项，已授权2项。主持和参与多项国家自然科学基金项目。本课题组的研究方向为非病毒型基因递送系统的研究及其在mRNA疫苗、基因治疗以及蛋白替代疗法中的研究与应用。在基因递送载体的设计与应用上处于国内前列，多项研究成果已在本行业领先企业成功转化。

教育和工作背景：

2020/12-至今，中山大学附属第七医院，科研中心，副研究员。

2018/09-2020/09，卡罗琳斯卡医学院（Karolinska Institutet），博士后。

2015/09-2018/06，武汉理工大学，材料科学与工程，博士

2013/09-2015/06，武汉理工大学，药学，硕士

2007/07-2013/05，东阳光药业，历任技术员，中试车间工艺员，中试车间主任。

2003/09-2007/06，武汉理工大学，制药工程，学士。

研究方向：

1. 结合机器学习、组合化学开展新型非病毒型基因递送载体的设计与研究。
2. 基于脂质的纳米颗粒递送系统（Lipid nanoparticle based gene delivery system）在mRNA疫苗、基因治疗以及蛋白替代疗法中的研究与应用。

近期代表性论文：

1. 1. G.-F. Zha^#, Q. Zheng^#, J. Leng, P. Wu, H.-L. Qin*, K. B. Sharpless*, Palladium-Catalyzed Fluorosulfonylvinylation of Organic Iodides, Angew. Chem. Int. Ed. 2017, 56, 4849-4852. (Co-first author, JCR1区，top期刊，IF:12.9，共同通讯作者为著名应用化学家，2001年诺贝尔化学奖得主K. B. Sharpless教授).
2. 2. G.-F. Zha^#, W.-Y. Fang^#, Y.-G. Li, J. Leng, X. Chen, H.-L. Qin*, SO₂F₂ Mediated Oxidative Dehydrogenation and Dehydration of Alcohols to Alkynes, J. Am. Chem. Soc. 2018, 140, 17666-17673. (Co-first author, JCR1区, top期刊，IF:14.6)

Featured by Chemistryviews: Direct Path from Alcohols to Alkynes

https://www.chemistryviews.org/details/news/11118968/Direct_Path_from_Alcohols_to_Alkynes.html

3. 3. G.-F. Zha^#, S.-M. Wang^#, K. P. Rakesh*, S. N. A. Bukhari, H. M. Manukumar, H. K. Vivek, N. Mallesh, H.-L. Qin*, Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections, Eur. J. Med. Chem. 2019, 162, 364-377. (高被引论文，Co-first author, JCR1区, top期刊，IF: 5.14)
4. 4. G.-F. Zha^#, W.-Y. Fang^#, J. Leng, H.-L. Qin*, Simple, Mild and Robust Oxidation of Alcohols to Aldehydes or Ketones Using DMSO as Solvent and Oxidant Mediated by SO₂F₂/K₂CO₃, Adv. Synth. Catal. 2019, 361, 2262-2267. (高被引论文，Co-first author, JCR1区，top期刊，IF: 5.12)
5. 5. H. Liu, B. Moku, F. Li, J. Ran, J. Han, S. Long*, G.-F. Zha*, H.-L. Qin, Stereoselective Construction of Nitrile-Substituted Cyclopropanes from 2-Substituted Ethenesulfonyl Fluorides via Carbon-Sulfur Bond Cleavage, Adv. Synth. Catal. 2019, 361, 4596-4601. (Corresponding author, JCR1区，top期刊，IF: 5.12)
6. 6. H. Liu, S. Long, K. P. Rakesh*, G.-F. Zha*, Structure-activity relationships (SAR) of triazine derivatives: Promising antimicrobial agents, Eur. J. Med. Chem., 2020, 185, 111804. (Corresponding author, JCR1区, top期刊，IF: 5.14)
7. 7. W.-Y. Fang^#, G.-F. Zha^#, H. -L Qin*, Making Carbonyls of Amides Nucleophilic and Hydroxyls of Alcohols Electrophilic Mediated by SO₂F₂ for Synthesis of Esters from Amides, Org. Lett. 2019, 21, 8657-8661 (Co-first author, JCR1区，top期刊，IF: 6.55)
8. 8. G.-F. Zha, H.-L. Qin*, B. G. M. Youssif, M. W. Amjad, M. A. G. Raja, A. H. Abdelazeem, S. N. A. Bukhari*, Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance, Eur. J. Med. Chem. 2017, 135, 34-48. (JCR1区, top期刊，IF: 5.14)
9. 9. G.-F. Zha, G. A. L. Bare, J. Leng, Z.-P. Shang, Z. Luo, H.-L. Qin*, Gram-scale synthesis of β-(Hetero)arylethenesulfonyl fluorides via a Pd(OAc)₂(cat.)/DDQ or AgNO₃ mediated oxidative Heck process, Adv. Synth. Catal. 2017, 359, 3237-3242. (JCR1区，top期刊，IF: 5.12)
10. 10. X. Chen^#, G.-F. Zha^#, G. A. L. Bare^#, J. Leng, S.-M. Wang, H.-L. Qin*, Synthesis of a class of fused δ-sultone heterocycles via DBU-catalyzed direct annulative SuFEx Click of ethenesulfonyl fluorides and pyrazolones or 1,3-dicarbonyl compounds, Adv. Synth. Catal. 2017, 359, 3254-3260.(Co-first author, JCR1区，top期刊，IF: 5.12)

个人邮箱：

zhagf@mail.sysu.edu.cn