Email：zzy990802@126.com

 

Education

2009-2012            Ph.D, the First Affiliated Hospital, Sun Yat-sen University, China.

2005-2008            M.D Medical College of Nantong University, Jiangsu, China.

1991-1995            Secondary Medical School,  Laiyang Secondary Medical School, Shandong, China.

Employment history

 

2017.07- present Associate professor, Orthopedic department, the Seventh Affiliated Hospital, Sun Yat-sen University, China

 

2017.01- present Vice director, Guangdong Provincial Key Laboratory of Orthopedics and Traumatology

 

2016.03-2018.03 AO fellow, AO Research Institute, Davos, 7270 Switzerland

 

2016.1-2017.06      Associate professor, Spine Surgery Department/Orthopedic Research Institute, the First Affiliated Hospital, Sun Yat-sen University, China

 

2012.11-2015.12   Post-doctor, Medical School of Shenzhen University and Sun Yat-sen University

 

2013.01-2014.12   director of R & D, Guangzhou Yijie Medicine Technology Co., Ltd

 

2012.6-2012.10        Research & Teaching Assistant, Spine Surgery Department/Orthopedic Research Institute, the First Affiliated Hospital, Sun Yat-sen University, China

 

2008.01-2009.08 Attending Surgeon, Longkou traditional hospital, Shandong, China

 

2005-2008        Research & Teaching Assistant, Medical College of Nantong University, China

 

1995-2005        Surgeon,  Xiadingjia Hospital, Longkou, Shandong, China.

 

Approved Research Projects(partly)

PI = Principal Investigator, CA = Co-Applicant, PR = Peer Reviewed

Source	Type	Title	Amount	Term
AOCMF, Davos, Switzerland	PI	The application research of the instructive bone regenerating hydrogel under the dynamic mechanical microenvironment	RMB 3580000	2022.02-2026.12
National Natural Science Foundation of China	PI, PR	The role and mechanism of piezo1 / 2 in regulating the osteo-inflammatory microenvironment of organoid bone repair materials under dynamic mechanical conditions	RMB 610,000	2021.01-2024.12
National Natural Science Foundation of China	PI, PR	The crosstalk mechanism of CD44 and HIF-1α related pathway in the regeneration of the degenerative nucleus pulposus activated by artificial nucleus pulposus and hypoxia	RMB 550,000	2018.01-2021.12
The National Key Research and Development Program of China	CA, PR	The innovation demonstration base of Southern China biomedical materials and implant equipment	RMB 860,000/28600000	2017.07-2021.06
Fundamental Research Funds for the Central Universities	PI, PR	Construction of organ like bone repair materials by biomicroprocessing of mesenchymal stem cell subsets	RMB 300,000	2019.01-2020.12
Foundation of Shenzhen Committee for Science and Technology Innovation	PI, PR	Construction and application of organoid bone repair materials	RMB 500,000	2019.01-2020.12
Foundation of Shenzhen Committee for Science and Technology Innovation	PI, PR	Construction and application of precise bionic organ like bone repair materials	RMB 200,000	2020.01-2021.12
Natural science foundation of Guangdong	PI, PR	the study of time window of biological therapy for lumbar intervertebral disc degeneration using T1rho-MR imaging	RMB 150,000	2014.01-2016.12
China Postdoctoral Science Foundation	PI, PR	the study of time window of biological therapeutic for  lumbar intervertebral disc degenerative disease using rhesus monkey model	RMB 100,000	2015.01-2017.12
China Postdoctoral Science Foundation	PI, PR	Establishing an ischemic intervertebral disc degenerative model of Rhesus monkey induced by sub-endplate injecting pingyangmycin	RMB 50,000	2013.01-2015.12

Active memberships in scientific societies

Member of SICOT Committee.

Committee member of Orthopaedic Research Branch of Chinese Medical Society.

Prizes, awards, fellowships

2014	COA Orthopaedics Research Awards 3rd Class

List of Publications: Peer-reviewed articles

Total number of published articles: 54; Total number of published first and corresponding author articles: 27

 

1.      Zhang, P.#, X. Liu#, P. Guo#, X. Li, Z. He, Z. Li, M. J. Stoddart, S. Grad, W. Tian, D. Chen*, X. Zou*, Z. Zhou* and S. Liu (2021). "Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration." Bioactive Materials 6(10): 3097-3108. DOI:10.1016/j.bioactmat.2021.02.024. （IF：14.593）

2.      Peng Guo#, Xizhe Liux#, Penghui Zhang#, Zhongyuan He, Zhen Li, Mauro Alini, R. Geoff Richards, Sibylle Grad, Martin J. Stoddart, Guangqiang Zhou, Xuenong Zou, Danny Channy, Wei Tian, Dafu Chen*, Manman Gao*, Zhiyu Zhou*, Shaoyu Liu A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration. Bioactive Materials （accepted）2021 （IF：14.593）

3.      Zhou, Zhiyu(#)，Jiang, Bo，Zhou, Zhiyang，Pan, Ximin，Sun, Haixing，Huang, Baoding，Liang, Tangzhao，Ringgaard, Steffen，Zou, Xuenong(*)，Intervertebral Disk Degeneration: T1 rho MR Imaging of Human and Animal Models，Radiology，2013.8.01，268（2）：492~500（IF：11.105）

4.      Ma J1, Guo W, Gao M, Huang B, Qi Q, Ling Z, Chen Y, Hu H, Zhou H, Yu F, Chen K, Richards G, Lin J, Zhou Z(*), Xiao D(*), Zou X(*). Biomimetic matrix fabricated by LMP-1 gene-transduced MC3T3-E1 cells for bone regeneration. Biofabrication. 2017 Nov 14;9(4):045010. doi: 10.1088/1758-5090/aa8dd1（IF：9.954）

5.      Ma, Junxuan(#)，Zhou, Zhiyu(#)，Gao, Manman，Yu, Binsheng，Xiao, Deming(*)，Zou, Xuenong(*)，B¨¹nger, Cody(*)，Biosynthesis of Bioadaptive Materials: A Review on Developing Materials Available for Tissue Adaptation，Journal of Materials Science & Technology，Volume 32, Issue 9, September 2016, Pages 810-814 （IF：8.067）

6.      Chen, Shaoming#，Gao, Manman#，Zhou, Zhiyu#，Liang, Jiabi，Gong, Ming，Dai, Xuejun，Liang, Tangzhao，Ye, Jiacheng，Wu, Gang，Zou, Lijin，wang yingjun，Zou Xuenong*，Opposite Regulation of Chondrogenesis and Angiogenesis in Cartilage Repair ECM Materials under Hypoxia，Journal of Materials Science & Technology(1005-0302)，2016.08.03，32（9）：978~985 （IF：8.067）

7.      Bao-Liang Li, Xizhe Liu, Manman Gao, Fu Zhang, Xu Chen, Zhongyuan He, Jianmin Wang, Wei Tian, Dafu Chen*, Zhiyu Zhou*, Shaoyu Liu Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model. Oxidative Medicine and Cellular Longevity （accepted）2021 （IF：6.453）

8.       L. Wen, M. Gao, Z. He, P. Guo, Z. Liu, P. Zhang, F. Zhang, D. Chen, G. Zhou, Z. Zhou, Noggin, an inhibitor of bone morphogenetic protein signaling, antagonizes TGF-β1 in a mouse model of osteoarthritis, Biochem Biophys Res Commun 570 (2021) 199-205. （IF：3.575）

9.      S. Cui, Z. Zhou#, X. Chen, F. Wei, R.G. Richards, M. Alini, S. Grad, Z. Li, Transcriptional profiling of intervertebral disc in a post-traumatic early degeneration organ culture model, JOR SPINE n/a(n/a)  e1146（IF：first year）

10.    Jianmin Wang#, Peixuan Zhu#,  Ximin Pan, Jun Yang, Shijun Wang,  Wentao Wang, Baoliang Li, Zhengya Zhu, Tao Tang, Dafu Chen*, Manman Gao*, Zhiyu Zhou* Correlation between motor behaviour and age-related intervertebral disc degeneration in cynomolgus monkeys JOR SPINE 2021 accepted（IF：first year）

11.    F. Zhang#, S. Wang#, B. Li, W. Tian, Z. Zhou*, S. Liu*, Intradiscal injection for the management of low back pain, JOR SPINE n/a(n/a)  e1186. （IF：first year）

12.    Huachuan Wu#, Kuileung Tong#, Xizhe Liu#, Jianfeng Li, Xianlong Li, Manman Gao, Wei Tian, Dafu Chen*, Zhiyu Zhou*, Shaoyu Liu, A comparison between two laminectomy procedures in mouse spinal cord injury on Allen‘s animal model, Journal of Neuroscience Methods 2021 accepted（IF：2.390）

13.    Shangbin Cui#, Zhiyu Zhou#, Xizhe Liu, R. Geoff Richards, Mauro Alini,Songlin Peng, Shaoyu Liu, Xuenong Zou, Zhen Li, Sibylle Grad* Identification and Characterization of Serum microRNAs as Biomarkers for Human Disc Degeneration: An RNA Sequencing Analysis. diagnostics 2020, 10(12) , 1063（IF：3.706）

14.    Zhiyu Zhou, Shangbin Cui, Jie Du, R. Geoff Richards, Mauro Alini, Sibylle Grad, Zhen Li. One Strike Loading Organ Culture Model to Investigate the Post-traumatic Disc Degenerative Condition. J Orthop Translat. 2020 Oct 20;26:141-150. doi: 10.1016/j.jot.2020.08.003. eCollection 2021 Jan. （IF：5.191）

15.    Zhiyu Zhou , Stephan Zeiter , Tanja Schmid , Daisuke Sakai  , James C. Iatridis , Guangqian Zhou , R. Geoff Richards, Mauro Alini , Sibylle Grad , and Zhen Li Effect of the CCL5-Releasing Fibrin Gel for Intervertebral Disc Regeneration  Cartilage 2018 https://doi.org/10.1177/1947603518764263（IF：4.634）

16.    Gao MM#, Su QN#, Liang TZ, Ma JX, Liang TZ, Stoddart MJ, Richards RG, Zhou ZY#, Zou NX#1. Transcriptional activation of ENPP1 by osterix in osteoblasts and osteocytes. Eur Cell Mater. 2018 Jul 25;36:1-14. doi: 10.22203/eCM.v036a01. （IF：3.942）

17.    Zhiyu Zhou(#)，Fuxin Wei(#)，Sheng Huang(#)，Manman Gao，Haisheng Li，Hans Stødkilde-Jørgensen，Martin Lind，Cody Bünger，Xuenong Zou(*)，InVivo Magnetic Resonance Imaging Evaluation of Porous Tantalum Interbody FusionDevices in a Porcine Spinal Arthrodesis Model，Spine，2015.10.1，40（19）：1471~8 （IF：3.468）

18.    Zhou, Zhiyu(#)，Gao, Manman(#)，Wei, Fuxin(#)，Liang, Jiabi，Deng, Wenbin，Dai, Xuejun，Zhou, Guangqian(*)，Zou, Xuenong(*)，Shock Absorbing Function Study on Denucleated Intervertebral Disc with or without Hydrogel Injection through Static and Dynamic Biomechanical Tests In Vitro，Biomed Research International，2014.3.5，8（1）：72~76 （IF：3.411）

19.    Zhou ZhiYu，Zou LiJin，Li HaiSheng，Bunger Cody，Zou XueNong(*)，An overview on bone protein extract as the new generation of demineralized bone matrix，Science China Life Sciences，2012.12.01，55（12）：1045~1056 （IF：6.038）

20.    Zhou, Zhiyang(#)，Zhou, Zhiyu(#)，Chen, Shaoming(#)，Li, Haisheng，Zou, Lijin，Ye, Jiacheng，Ringgaard, Steffen，Bunger, Cody，Zou, Xuenong(*)，T1 rho-MR imaging technique to distinguish four-layered zonal structure of articular cartilage for detecting early-onset osteoarthritis，Journal of X-Ray Science and Technology，2012.01.01，20（4）：437~446 （IF：1.535）

21.    Chen, Da-Fu(#)，Zhou, Zhi-Yu(#)，Dai, Xue-Jun(#)，Gao, Man-Man，Huang, Bao-Ding，Liang, Tang-Zhao，Shi, Rui，Zou, Li-Jin，Li, Hai-Sheng，Bunger, Cody，Tian, Wei(*)，Zou, Xue-Nong(*)，Time-sequential changes of differentially expressed miRNAs during the process of anterior lumbar interbody fusion using equine bone protein extract, rhBMP-2 and autograft，FRONTIERS OF MATERIALS SCIENCE，2014.3.01，8（1）：72~86 （IF：2.765）

22.    Fuxin Wei(#)，Rui Zhong(#)，Zhiyu Zhou(#)，Le Wang，Ximin Pan，Shangbin Cui，Xuenong Zou，Manman Gao，Haixing Sun，Wenfang Chen，Shaoyu Liu(*)，In vivo experimental intervertebral disc degeneration induced by bleomycin in the rhesus monkey，BMC Musculoskelet Disord，2014.10.9，15（340） （IF：2.362）

23.    Fuxin Wei(#)，Le Wang(#)，Zhiyu Zhou(#)，Rui Zhong，Shaoyu Liu(*)，Shangbin Cui，Ximin Pan，Manman Gao，Cervical cage without plating in management of type II _ II A Hangman’s fracture combined with intervertebral disc injury，BMC Musculoskeletal Disorders，2015.10.6，16（285） （IF：2.362）

24.    Fuxin Wei(#)，Ximin Pan(#)，Zhiyu Zhou(#)，Shangbin Cui，Rui Zhong，Le Wang，Manman Gao，Ningning Chen，Zijian Liang，Xuenong Zou，Sheng Huang，Shaoyu Liu(*)，Anterior-only stabilization using cage versus plating with bone autograft for the treatment of type II/IIA Hangman’s fracture combined with intervertebral disc injury，J Orthop Surg Res，2015.3.11，10（33） （IF：2.359）

25.    Wei, F(#)，Zhou, Z(#)，Wang, L(#)，Liu, S，Zhong, R，Liu, X，Cui, S，Pan, X，Gao, M，Zhao, Y，Biomechanical evaluation of monosegmental pedicle instrumentation in a calf spine model and the role of fractured vertebrae in screw stability，BMC Vet Res . 2016 Mar 18;12:5，12：57 （IF：2.741）

26.    周治宇(#)，邹立津，李海声，Cody Bünger，邹学农(*)，骨蛋白提取物:新一代基于脱钙骨基质的骨修复材料，中国科学:生命科学，2012.01.01，（12）：974~985

27.    22.   (2) 梁嘉碧(#)，李俊，汪婷，梁雨虹，邹学农，周光前，周治宇(*)，原位交联透明质酸水凝胶的制备及体外生物相容性研究，中国修复重建外科杂志，2016.5.01，（06）：767~771