Ningning Li’s group use the Flp-Frt and CreER-LoxP dual-system mouse models to detect and track the origin cells of tumors (such as breast cancer, pancreatic cancer, and glioma) for molecular target screening. Further expand the study of tumors and stroma, as well as neurodegenerative diseases, development of glia cells and gut-brain axis, considering biological and clinical significance. Long-term research interests aim to comprehensively explain the pathogenesis of these diseases from the perspective of multi-dimensional big data such as omics, molecular pathology and imaging, screen biomarkers and drug targets, and establish an effective and accurate diagnosis and treatment system.
Education and employment
Dec 2017 – present Associate professor, PI, PhD student & postdoc supervisor, The 7th Affiliated Hospital of Sun Yat-sen University (SYSU), Shenzhen, China.
Jun 2017 – Dec 2017 Research fellow, Francis Crick Institute, London, UK. (Senior PI: Dr. Axel Behrens, fellow of Academia Europaea) May 2013 – May 2017 Senior research associate, official PhD student supervisor, Institute of Neurology (IoN), University College London (UCL), UK. (Department director: Prof. Sebastian Brandner)
Oct 2008 – Apr 2013 Ph.D. (Distinction Viva) & Post-doc assistant, School of Clinical Sciences,UoN, UK. (Supervisor: Dr. Abdolrahman Shams Nateri; Examiner: Prof. Alan Clarke) Sept 2005 – Jul 2008 M.Sc. Dept. of Biology, Laurentian University, Canada. (Supervisor: Prof. Hoyun Lee)
Aug 2004 – Aug 2005 Research assistant, State Key Laboratory of Biotherapy,West
China Medical School, Sichuan University, China.
Sept 2000 – Jul 2004 B.Sc. Dept. of Bioengineering, Southwestern Uni of Sci & Tech (SWUST), China.
Publications
Up-and-coming:
1. Ningning Li, Roya Babaei-Jadidi, Bradley Spencer-Dene, and Abdolrahman S. Nateri. “SCFFBXW7 Links Intestinal Stem Cells to EMT in Carcinogenesis” (Nature Communications, under revision)
2. Ying Zhang, Stefan Pusch, Kastytis Sidlaukas, Matt Ellis, Joanne Lau, Angela Richard-Londt, Francesca Launchbury, Tasha Aley, Andreas von Deimling, Ningning Li§ and Sebastian Brandner§. “Mutant IDH1 sensitizes brain tumours to endoplasmic reticulum stress and trigger apoptosis through miR-183/Sema3e axis”. (submitted to Nature Cell Biology) (§co-corresponding author)
Recently published:
1. Xibo Li*, Ningning Li*, Kastytis Sidlauskas, Houli Li, Chao Zhang, Mingli Peng, Qinlu Zhang, Kai Hua, Lili Guo, Fuqiang Li, Ying Zhang, Mingwei Chen, Guanjun Zhang, Yihang Pan, Linlin Gao, and Yali Cui. “Doxorubicin-Loaded Dextran-Modified GoldMag Nanoparticles for Targeting Hepatocellular Carcinoma”. Journal of Biomedical Nanotechnology. 2018 Jun 14;6, pp.1135-1146(12). (*co-first authorship) (IF: 7.6)
2. Guo-Hao Huang, Lei Du, Ningning Li, Ying Zhang, Yan Xiang, Jun-Hai Tang, Shuli Xia, Eric Erquan Zhang,Sheng-Qing Lv. “Methylation-mediated miR-155-FAM133A axis contributes to the attenuated invasion and migration of IDH mutant gliomas”. Cancer Letters. 2018 Jun (IF: 6.5)
3. Ningning Li§, Ying Zhang, Kastytis Sidlauskas, Matthew Ellis, Ian Evans, Paul Frankel, Joanne Lau, Tedani El-Hassan, Loredana Guglielmi, Jessica Broni, Angela Richard-Loendt & Sebastian Brandner§. “Inhibition of GPR158 by microRNA-449a suppresses neural lineage of glioma stem/progenitor cells and correlates with higher glioma grades”. Oncogene. 2018 May (IF: 8.5) (first author & co-corresponding author)
4. Xiaonan Liu, Chao Zhang, Mengye Zhao, Kewu Liu, Hang Li, Ningning Li, Linlin Gao, Xuemin Yang, Ting Ma,Juanli Zhu, Wenli Hui, Kai Hua, Yali Cui. “A direct isothermal amplification system adapted for rapid SNP genotyping of multifarious sample types”. Biosensors and Bioelectronics. 2018 May 115, 70–76 (IF: 7.8)
5. Yubin Huang, Zhen Xu, Shanshan Xiong, Fangfang Sun, Guangrong Qin, Guanglei Hu, Jingjing Wang, Lei Zhao, Yu-Xiang Liang, Tianzhun Wu, Zhonghua Lu, Mark S. Humayun, Kwok-Fai So, Yihang Pan, Ningning Li, Ti-Fei Yuan, Yanxia Rao and Bo Peng. “Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion”. Nature Neuroscience. 2018 Apr, 21(4):530-540. (IF: 17.8)
6. Valeria Amodeo, Deli A, Joanne Betts, Stefano Bartesaghi, Ying Zhang, Angela Richard-Londt, Matthew Ellis, Rozita Roshani, Mikaella Vouri, Sara Galavotti, Sarah Oberndorfer, Ana Paula Leite, Alan Mackay, Aikaterini Lampada, Eva Wessel Stratford, Ningning Li, David Dinsdale, David Grimwade, Paolo Salomoni. “APML/Slit Axis Controls Physiological Cell Migration and Cancer Invasion in the CNS”. Cell Rep. 2017 Jul 11;20(2):411-426. doi: 10.1016/j.celrep.2017.06.047. (IF: 8.5)
7. Kastytis Sidlauskas, Ruta Sidlauskiene, Ningning Li, and Julius Liobikas. “5-Hydroxy-1,4-naphthalenedione exerts anticancer effects on glioma cells through interaction with the mitochondrial electron transport chainNeuroscience” Letters. 2017, 639: 207-214. (IF: 2.0)
8. Antonina Frolov, Ian M Evans, Ningning Li, Kastytis Sidlauskas, Ketevan Paliashvili, Nicola Lockwood, Angela Barrett, Sebastian Brandner, Ian C Zachary, and Paul Frankel. “Imatinib and Nilotinib increase glioblastoma cell invasion via Abl-independent stimulation of p130Cas and FAK signalling” Scientific Reports. 2016, 6: 27378-27389 (IF: 5.2)
9. Jun-Hai Tang, Zhi-Xiong Ma, Guo-Hao Huang, Qing-Fu Xu, Yan Xiang, Ningning Li, Kastytis Sidlauskas, Eric Erquan Zhang, and Sheng-Qing Lv. “Downregulation of HIF-1a sensitizes U251 glioma cells to the temozolomide (TMZ) treatment” Experimental Cell Research. 2016, 343: 148-158. (IF: 3.2)
10. Guo-Hao Huang, Qing-Fu Xu, You-Hong Cui, Ningning Li, Xiu-Wu Bian, and Sheng-Qing Lv. “Medulloblastoma stem cells: promising targets in medulloblastoma therapy” Cancer Science. 2016, 107(5): 583-589. (IF: 3.5) 11. Wenli Hui, Sinong Zhang, Chao Zhang, Yinsheng Wan, Juanli Zhu, Gang Zhao, Songdi Wu, Dujuan Xie, Qinlu Zhang, Ningning Li, and Yali Cui. “A Novel Lateral Flow Assay Based on GoldMag Nanoparticles and Its Clinical Applications for Genotyping of MTHFR C677T Polymorphisms” Nanoscale. 2016, 8: 3579-3587.(IF: 7.4)
12. Ningning Li, Federica Lorenzi, Eliana Kalakouti, Makhliyo Normatova, Roya Babaei-Jadidi, Ian Tomlinson,and Abdolrahman S. Nateri. “FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15” Oncotarget. 2015, 6(11): 9240-9256 (IF: 6.0)
13. Songdi Wu, Ningning Li, Feng Xia, Kastytis Sidlauskas, Xuemei Lin, Yihua Qian, Wei Gao and Qinlu Zhang.“Neurotrophic keratopathy due to dorsolateral medullary infarction (Wallenberg Syndrome): case report and literature review” BMC neurology. 2014, 14(1): 231-234. (IF: 2.8)
14. Angela Barrett, Ian M Evans, Antonina Frolov, Gary Britton, Caroline Pellet-Many, Maiko Yamaji, Vedanta Mehta, Rina Bandophadyay, Ningning Li, Sebastian Brandner, Ian C Zachary, and Paul Frankel. “Critical role for DOK1 in PDGF-BB stimulated glioma cell invasion via p130Cas and Rap1 signalling” Journal of Cell Science. 2014, 127: 2647-2658. (IF: 5.0)
15. Dong Yang, Jianzhong Ma, Qinlu Zhang, Ningning Li, Paul Raju, Mingli Peng, Yanling Luo, Wenli Hui, Chao Chen, and Yali Cui. “Polyelectrolyte Coated Gold Magnetic Nanoparticles for Immunoassay Development:Toward Point of Care Diagnostics for Syphilis Screening" Analytical Chemistry. 2013, 85(14): 6688-6695. (IF: 5.8)
16. ELSayed E. Ibrahim, Roya Babaei-Jadidi, Anas Saadeddin, Bradley Spencer-Dene, Sina Hossaini, Mohammed Abuzinadah, Ningning Li, Wakkas Fadhil, Mohammad Ilyas, Dominique Bonnet, and Abdolrahman S. Nateri. “Embryonic NANOG Activity Defines Colorectal Cancer Stem Cells and Modulates through AP1- and TCF-dependent Mechanisms”. Stem Cells. 2012, 30(10): 2076-2087. (IF: 8.6)
17. Roya Babaei-Jadidi*, Ningning Li*, Anas Saadeddin, Bradley Spencer-Dene, Anett Jandke, Belal Muhammad, ELSayed E. Ibrahim, Ranjithmenon Muraleedharan, Mohammed Abuzinadah, Hayley Davis, Annabelle Lewis, Susan Watson, Axel Behrens, Ian Tomlinson, and Abdolrahman S. Nateri. “FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun and DEK for degradation” Journal of Experimental Medicine. 2011, 208: 295-312 (*co-first authorship) (IF: 15)
18. Yan Chen, Xiao-yan Lin, Zhi-rong Yang, and Ningning Li. “Optimization of Extracting Condition of Flavonoids from Bambusa Multiple Leaves”. Chemical Research & Application (in Chinese). 2004, Vol. 6. Issue 2. 292-293.
Email Address：linn29@mail.sysu.edu.cn