个人简介

     钟理，中山大学附属第七医院副研究员，博士生导师，深圳市高层次人才。主要研究方向：肿瘤新靶标的鉴定、调控与干预。研究成果主要发表在Nature Cell Biology、Science Advances、Journal of Clinical Investigation, Cell Reports Medicine、Signal Transduction and Targeted Therapy、Advanced Science、Oncogene、Cancer letters等期刊，主持国家自然科学基金面上等项项目等。

教育工作经历

2021/8-至今，中山大学附属第七医院，副研究员

2018/8—2021/7，中山大学肿瘤防治中心，博士后

2013/09-2018/06，中山大学肿瘤防治中心，分子医学，理学博士

2009/09-2013/06，中山大学生命科学学院，生物科学，理学学士

研究内容

1. 鉴定肿瘤转移的潜在靶标

肿瘤转移是一个复杂的多步骤过程：肿瘤细胞从原发灶中脱离，通过血液循环抵达远端转移器官，定植存活并增殖，最终形成肿瘤转移灶。我们主要研究肿瘤细胞与原位微环境以及转移靶器官微环境的相互作用机制，鉴定在肿瘤转移进程中发挥重要作用的细胞亚群和分子，从而建立靶向肿瘤转移（肿瘤-微环境互作）的治疗策略（Nat Cell Biol, 2020; Signal Transduct Target Ther; 2021; Adv Sci, 2023、2025; J Clin Invest, 2025）。

2. 寻找基于一线药物的联合疗法

我们主要基于CRIPSR文库筛选，鉴定肿瘤复发耐药的调控分子，旨在发现联合治疗新方法，改善肿瘤一线药物的疗效（Sci Adv, 2023; Cancer Letters, 2024；Oncogene, 2025）。

发表论文（#第一作者，*通讯作者）

(1) Cuiling Zeng#, Xin Wang#, Jinkun Zhong, Yu Zhang, Ju Deng, Wenqiang Liu, Weixuan Chen, Xinhao Yu, Dian Lin, Ruhua Zhang, Shang Wang, Jianpei Lao, Qi Zhao, Li Zhong*, Tiebang Kang*, Dan Liao*. PIM3-mediated phosphorylation stabilizes myeloid leukemia factor 2 to promote metastasis in osteosarcoma. Journal of Clinical Investigation. 2025 Oct 15;135(20):e191040. 

(2) Huafeng Fu#, Jie Zhang#, Hengxing Chen#, Haobin Hou#, Huanjie Chen, Rongman Xie, Yanlei Chen, Jian Zhang, Dehua Liu, Leping Yan, Rui L. Reis, Joaquim M. Oliveira, Yulong He*, Li Zhong*, Qinbo Cai*, Dongjie Yang*. NPR1 Promotes Lipid Droplet Lipolysis to Enhance Mitochondrial Oxidative Phosphorylation and Fuel Gastric Cancer Metastasis，Advanced Science, 2025 Oct;12(37):e03233. 

(3) Jingxuan Wang#, Lisi Zheng#, Wanqi Chen#, Xia Zhang, Dongming Lv, Cuiling Zeng, Changlin Zhang, Ruhua Zhang, Tiebang Kang, Li Zhong*. Targeting RBM39 suppresses tumor growth and sensitizes osteosarcoma cells to cisplatin. Oncogene. 2025 Mar;44(9):575-586

(4) Weijie Gao#, Jing Zhou#, Jintao Huang#, Zhiguang Zhang, Wanqi Chen, Ruhua Zhang, Tiebang Kang, Dan Liao*, Li Zhong*. Up-regulation of RAN by MYBL2 maintains osteosarcoma cancer stem-like cells population during heterogeneous tumor generation. Cancer Letters. 2024 Feb 7:586:216708

(5) Miao Li#, Chang-Lin Zhang#, Di-Sheng Zhou#, Sze-Hoi Chan, Xue-Qi Liu, Shu-Na Chen, Zi-Yi Yang, Fei-Er Ju, Xiao-Yan Sang, Zi-Xuan Liu, Qiao-Xia Zhang, Yu-Ming Pan, Si-Si Deng, Xiao-Mei Wang, Li Zhong*, Xing-Ding Zhang*, Xin Du* Identification of COQ2 as a regulator of proliferation and lipid peroxidation through genome-scale CRISPR-Cas9 screening in myeloma cells. Br J Haematol. 2024 Mar 10. doi: 10.1111/bjh.19375

(6) Li Zhong#, Jingxuan Wang#, Wanqi Chen#, Dongming Lv, Ruhua Zhang, Xin Wang, Cuiling Zeng, Xiaobo He, Lisi Zheng, Ying Gao, Shang Wang, Miao Li, Yuanzhong Wu, Junqiang Yin*, Tiebang Kang*, Dan Liao*. Augmenting L3MBTL2-induced condensates suppresses tumor growth in osteosarcoma. Science Advances.2023 Nov 24;9(47): eadi0889.

(7) Cuiling Zeng#, Li Zhong#, Wenqiang Liu#, Yu Zhang, Xinhao Yu, Xin Wang, Ruhua Zhang, Tiebang Kang*, Dan Liao*. Targeting the lysosomal degradation of Rab22a-NeoF1 fusion protein for osteosarcoma lung metastasis. Advanced Science. 2023 Feb;10(5):e2205483

(8) Dongming Lv#, Xiaoling Cao#, Li Zhong#, Yunxian Dong, Zhongye Xu, Yanchao Rong, Hailin Xu, Zhiyong Wang, Hao Yang, Rong Yin, Miao Chen, Chao Ke, Zhicheng Hu*, Wuguo Deng*, Bing Tang*. Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing. Cell Reports Medicine. 2023 Aug 15;4(8):101129.

(9) Zhanglin Zhang#, Lixiang Liu#, Weizhao Li#, Mengxiong Li#, Xunzhi Zhang#, Chi Zhang, Huan Yang, Jiayuan Xie, Wei Pan, Xue Guo, Peng She*, Li Zhong*, Tian Li*. Upregulation of FAM83F by c-Myc promotes cervical cancer growth and aerobic glycolysis via Wnt/β-catenin signaling activation. Cell Death & Disease. 2023 Dec 16;14(12):837.

(10) Shang Wang#, Yuqing Li#, Li Zhong#, Kai Wu, Ruhua Zhang, Tiebang Kang, Song Wu*, Yuanzhong Wu*. Efficient gene editing through an intronic selection marker in cells. Cellular and Molecular Life Sciences，2022, 79, 111.

(11) Li Zhong#, Dan Liao#, Jingjing Li#, Wenqiang Liu, Jingxuan Wang, Cuiling Zeng, Xin Wang, Zhiliang Cao, Ruhua Zhang, Miao Li, Kuntai Jiang, Yi-Xin Zeng, Jianhua Sui*, Tiebang Kang*. Rab22a-NeoF1 fusion protein promotes osteosarcoma lung metastasis through its secretion into exosomes. Signal Transduction and Targeted Therapy, 2021 Feb 11;6(1):59.

(12) Dan Liao#, Li Zhong#, Junqiang Yin#, Cuiling Zeng, Xin Wang, Xingchuan Huang, Jinna Chen, Hong Zhang, Ruhua Zhang, Xin-Yuan Guan, Xintao Shuai, Jianhua Sui, Song Gao, Wuguo Deng, Yi-Xin Zeng, Jing-Nan Shen*, Jian Chen*, Tiebang Kang*. Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma. Nature Cell Biology, 2020 Jul;22(7):868-881.

(13) Li Zhong#, Dan Liao#, Meifang Zhang, Cuiling Zeng, Xinchun Li, Ruhua Zhang, Haiqing Ma* Tiebang Kang*. YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma. Cancer Letters, 2019 Feb 1;442:252~261.

(14) Shang Wang#. Li Zhong#, Yin Li#, Desheng Xiao, Ruhua Zhang, Dan Liao, Dongming Lv, Xin Wang, Juanfei Wang; Xianbiao Xie; Jing Chen*; Yuanzhong Wu*, Tiebang Kang*. Up-regulation of PCOLCE by TWIST1 promotes metastasis in Osteosarcoma. Theranostics, 2019 Jun 9;9(15):4342-4353. 

(15) Xinchun Li#, Li Zhong#, Zhuo Wang#, Huiming Chen, Dan Liao. Ruhua Zhang, Hongyu Zhang*, Tiebang Kang*. Phosphorylation of IRS4 by CK1 gamma 2 promotes its degradation by CHIP through the ubiquitin/lysosome pathway. Theranostics, 2018 Jun 7;8(13):3643-3653

博士后招聘：

本课题组长期招收肿瘤细胞生物学等相关专业的博士后，欢迎国内外优秀博士毕业生加盟！

个人邮箱：

zhongli@sysush.com; zhongli7@mail.sysu.edu.cn