个人简介： 

      卢盈颖，特聘副研究员、硕士生导师。香港大学医学院细胞生物学博士。目前实验室主要研究方向为自噬/细胞内膜运输途径在细胞应激，肿瘤生长转移，及病毒感染中的作用机制。作为（共同）第一作者/通讯作者在 Acta Pharmaceutica Sinica B，Signal Transduction and Targeted Therapy、Autophagy，Frontier in immunology，FEBS Letter，J Biomedical Science等著名学术期刊发表SCI论文10余篇。作为项目负责人承担国家自然科学基金青年基金一项，广东省前沿与关键技术创新专项资金-粤港联合创新项目一项。目前获得已授权的中国国家专利一项，深圳市科技创新委员会颁发的“省级科技项目奖”一次。

主要发表论文：

1. Lu Y.Y.#, Liu F.#, Tong G.L.#, Qiu F., Song P. H., Wang X.L., Zou X.F., Wan D.Y., Cui M., Xu Y.S., Zheng Z.H., Hong P*. Clinical evidence of an interferon–glucocorticoid therapeutic synergy in COVID-19. Signal Transduction and Targeted Therapy 6(1):107.

2. Tang, Y.C.# , Wang L.M.# , Yi, T., Xu, J., Wang, J.Q., Qin, J.J., Chen, Q.L., Yip, K.M., Pan, Y.H., Hong, P., Lu Y.Y.* Shen, H.M.,* Chen, H.B.* Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy. Acta Pharmaceutica Sinica B (2021.05.13 Accepted) (* Corresponding author)

3. Wang X.W.*, Yang Y., Cai W. Q., Lu Y.Y.*. (2020) The Relationship of Sphingosine Kinase 1 With Pyroptosis Provides a New Strategy for Tumor Therapy. Front Immunol 2;11:574990.  (* Corresponding author)

4. Wang X.W.*, Sun Y., Peng X.C., Naqvi SMAS, Yang Y., Zhang J., Chen M.W.W., Chen Y., Chen H.Y., Yan H.Z., Wei G.L., Hong P., Lu Y.Y.*. (2020) The Tumorigenic Effect of Sphingosine Kinase 1 and Its Potential Therapeutic Target. Cancer Control 27(1):1073274820976664.  (* Corresponding author)

5. Chen C.#, Lu Y.Y.#, Siu H.M.#, Guan J.T., et al. Identification of Novel Vacuolin-1 Analogues as Autophagy Inhibitors by Virtual Drug Screening and Chemical Synthesis. Molecules, 2017, 22 (6) e891. (# equal contribution）

6. Lu Y.Y., Dong S.C., Hao B.X., et al. Vacuolin-1 Potently and Reversibly Inhibits Autophagosome-Lysosome Fusion by Activating RAB5. Autophagy, 2014, 10: 1-12.

7. Lu Y.Y., Chen T.S., Wang X.P., Qu J. L. The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cells. FEBS Lett. 2010, 584: 4019-4026.

8. Lu Y.Y., Chen, T.S., Wang, X.P., Li L. Single cell analysis of dihydroartemisinin (DHA)-induced apoptosis through reactive oxygen species (ROS)-mediated caspase-8 activation and mitochondrial pathway in ASTC-a-1 cells using fluorescence imaging techniques. J. Biomed. Opt. 2010, 15: 046028-1-16.

9. Lu Y.Y., Chen T.S., Qu J.L., Pan W.L., et al. Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma cells. J. Biomed. Sci. 2010, 16: 1-16.

个人邮箱：

luyy39@sysu.edu.cn