M.D，Ph.D，研究员，硕士生导师，博士生导师，博士后合作导师

中山七院副院长、中山大学医学院副院长，

中山七院精准医学中心主任、基础医学教研室主任、科研中心常务副主任、临床医学研究大数据中心执行主任、广东省消化系统恶性肿瘤防治研究重点实验室副主任；中山大学医学院病理学系主任

个人简介：

中山医科大学临床医学专业学士，美国路易斯安那州立大学医学中心细胞生物学博士、康奈尔大学医学院博士后、美国医学遗传学学院临床Fellow。曾就职于康奈尔大学医学院附属医院病理科6年，从事基因检测、诊断的临床工作。有中美两国的临床实践及医学研究工作经历近30年，在解读与疾病和健康相关的遗传学因素方面有丰富的临床经验。作为一名资深精准医学领域的科学家，潘逸航博士带领其课题组团队致力于疾病精准诊疗多学科交叉研究。近五年，在Advanced Materials、Gut、Signal Transduction and Targeted Therapy、Biomaterials、Drug Resistance Updates、Advanced Science、British Journal of Cancer、BMC Medicine等国际期刊发表通讯作者论文40来篇，申请国内外专利十余项，参与撰写指南两件，担任多个SCI杂志审稿人，主持或参与10余项国家级等科研项目，包含主持两项国家重点研发计划课题、一项国自然面上项目、一项省重点研发项目（Co-PI）。担任中国医院协会精准医疗分会等多个学会副主任委员。

研究领域：

(1). 纳米医学

针对肿瘤治疗脱靶、疗效差、耐药等问题，主要开展以新型金属基纳米材料为生物活性药物的构建与抗肿瘤应用。

近期代表性研究成果：

（1） Yuzhi Xu#, Si-Yang Liu#, Leli Zeng*, Hansu Ma, Yanfei Zhang, Huihui Yang, Yuchen Liu, Shuo Fang, Jing Zhao, Yunsheng Xu, Charles R. Ashby Jr, Yulong He*, Zong Dai*, Yihang Pan*. An Enzyme-Engineered Nonporous Copper(I) Coordination Polymer Nanoplatform for Cuproptosis-based Synergistic Cancer Therapy. Advanced Materials, 2022 Sep, 34(43):e2204733.

（2） Jia Li#, Leli Zeng#*, Zheng Wang, Hengxing Chen, Shuo Fang, Jinquan Wang, Chao-Yun Cai, Enming Xing, Xinxing Liao, Zhi-Wei Li, Charles R. Ashby Jr, Zhe-Sheng Chen*, Hui Chao*, Yihang Pan*. Cycloruthenated Self-Assembly with Metabolic Inhibition to Efficiently Overcome Multidrug Resistance in Cancers. Advanced Materials, 2022 Jan, 34(1), e2100245.

（3） Guochuang Chen#, Leli Zeng#, Bo Bi, Xiuyu Huang, Miaojuan Qiu, Ping Chen, Zhi-Ying Chen, Yulong He, Yihang Pan*, Yu Chen*, Jing Zhao*. Engineering Bifunctional Calcium Alendronate Gene-Delivery Nanoneedle for Synergistic Chemo/Immuno-Therapy Against HER2 Positive Ovarian Cancer. Advanced Science, 2023 March 18, 10(14):2204654.

（4） Tao Feng, Zixin Tang, Johannes Karges, Jinchao Shen, Chengzhi Jin, Yu Chen, Yihang Pan*, Yulong He*, Liangnian Ji, Hui Chao*, Exosome camouflaged coordination-assembled Iridium(III) photosensitizers for apoptosis-autophagy-ferroptosis induced combination therapy against melanoma. Biomaterials, 2023 Jun 24, 301:122212.

（5） Jing Zhao, Xiuyu Huang, Peng Liu, Miaojuan Qiu, Binbin Li, Yingfei Wen, Yongshu Li, Qiang Wang, Meiying Wu*, Yu Chen*, Yihang Pan*. Engineering Alendronate-Composed Iron Nanochelator for Efficient Peritoneal Carcinomatosis Treatment. Advanced Science, 2022 Sep, 9(30):e2203031.

(2). 分子医学

针对肿瘤发生发展，尤其肿瘤耐药等问题，主要开展新靶点挖掘与基因线路机制探索。

近期代表性研究成果：

（1） Zi-Ning Lei#, Qiu-Xu Teng#, Qin Tian#, Wei Chen#, Yuhao Xie, Kaiming Wu, Qianlin Zeng, Leli Zeng*, Yihang Pan*, Zhe-Sheng Chen*, Yulong He*. Signaling pathways and therapeutic interventions in gastric cancer. Signal Transduction and Targeted Therapy, 2022 Oct, 7(1):358.

（2） Jinxiang Wang#, Leli Zeng#, Nisha Wu, Yanling Liang, Jie Jin, Mingming Fan, Xiaoju Lai, Zhe-Sheng Chen, Yihang Pan*, Fangyin Zeng*, Fan Deng*, Inhibition of Phosphoglycerate dehydrogenase induces ferroptosis and overcomes enzalutamide resistance in castration-resistant prostate cancer cells. Drug Resistance Updates, 2023 Sep, 70:100985.

（3） Hailin Zou#, Juan Luo#, Yibo Guo, Liang Deng, Leli Zeng, Yihang Pan*, Peng Li*, Tyrosine phosphorylation-mediated YAP1-TFAP2A interactions coordinate transcription and trastuzumab resistance in HER2+ breast cancer. Drug Resistance Updates, 2024 Mar, 73: 101051.

（4） Juan Luo#, Hailin Zou#, Yibo Guo, Tongyu Tong, Yun Chen, Yunjun Xiao, Yihang Pan*, Peng Li*, The oncogenic roles and clinical implications of YAP/TAZ in breast cancer, British Journal of Cancer, 2023 Feb, 128(9):1611-1624.

（5） Zi-Ning Lei, Qin Tian, Qiu-Xu Teng, John N.D. Wurpel, Leli Zeng*, Yihang Pan*, Zhe-Sheng Chen*. Understanding and targeting resistance mechanisms in cancer. MedComm, 2023 May, 4(3): e265.

(3). 临床医学大数据

针对消化道疾病、肿瘤等疾病的发生及预后，进行多影响因素的大型队列数据分析。

近期代表性研究成果：

（1） Qiangsheng He, Chongfei Huang, Xiwen Qin, Yuanyuan Yu, Di Tang, Junjie Huang, Zi Chong Kuo, Yuyao Ling, Deli Mao, Bin Xia, Wenjing Li, Kuiqing Lu, Man Yang, Yulong He, Wenbo Meng*, Jinqiu Yuan*, Yihang Pan*, Confounded association between proton pump inhibitor use and risk of biliary tract cancer: Result from three cohorts, International Journal of Cancer, 2023 May, 153(5): 942-949.

（2） Man Yang#, Qiangsheng He#, Fang Gao, Krish Nirantharakumar, Tonny Veenith, Xiwen Qin, Amy T Page, Martin C S Wong, Junjie Huang, Zi Chong Kuo, Bin Xia, Changhua Zhang, Yulong He, Wenbo Meng*, Jinqiu Yuan*, Yihang Pan*. Regular use of proton-pump inhibitors and risk of stroke: a population-based cohort study and meta-analysis of randomized-controlled trials. BMC Medicine, 2021 Dec, 19(1), 316.12.

（3） Qiangsheng He#, Man Yang, Xiwen Qin, Die Fan, Jinqiu Yuan*, Yihang Pan*. Risk stratification for proton pump inhibitor-associated type 2 diabetes: a population-based cohort study. Gut, 2021 Nov, 70(11), 2212-2213.

（4） Qiangsheng He#, Bin Xia#, Wenbo Meng#, Die Fan, Zi-Chong Kuo, Junjie Huang, Xiwen Qin, Huachun Zou, Yulong He, Changhua Zhang, Shuo Fang, Yihang Pan*, Man Yang*, Jinqiu Yuan*. No Associations Between Regular Use of Proton Pump Inhibitors and Risk of All-Cause and Cause-Specific Mortality: A Population-Based Cohort of 0.44 Million Participants. American Journal of Gastroenterology, 2021 Nov, 116(11), 2286-2291.

（5） Jinqiu Yuan#, Yanhong Jessika Hu, Jie Zheng, Jean Hee Kim, Tim Sumerlin, Youpeng Chen, Yulong He, Changhua Zhang, Jinling Tang, Yihang Pan*, Michael Moore*. Long-term use of antibiotics and risk of type 2 diabetes in women: a prospective cohort study. International Journal of Epidemiology, 2020 Oct, 49(5), 1572-1581.

研究生招生和博后招聘

1） 研究生招生：中山七院（学科：基础医学），中山大学医学院（学科：生物与医药），两边均可招生；

2） 博士后招聘（不限方向，长期招聘，深圳待遇，中大质量，欢迎随时咨询）

3） 科研助理招聘：医学、生物学等相关学科背景专业者优先。

课题组经费充足，氛围融洽，具有从副研究员、助理研究员、博士后到博士生、硕士生的人才培养与成长的完整体系，能为不同层次和不同学科背景的优秀学子提供优越的求学与成才平台。

联系方式

panyih@mail.sysu.edu.cn