个人简介：

现任中山大学附属第七医院副研究员，硕士生导师，中山大学“百人计划”引进人才。于2016年获得香港中文大学病理解剖及细胞学专业博士。曾于2016-2019年在香港中文大学病理解剖学及细胞学系任博士后, 2020年8月通过中山大学“百人计划”引进人才加入中山大学附属第七医院科研中心任职。目前主要研究方向包括：1.  表观遗传修饰在癌症发生发展中作用机制；2.  肝癌中基因组，转录组，表观遗传组和免疫微环境的异质性；3.  突变基因与异常表达的蛋白质，非编码RNA等在癌症发生发展的作用机制及临床应用。目前研究成果主要发表在Gastroenterology, Hepatology等杂志上。

教育背景：

2004/09-2008/06  中山大学   生物技术   学士

2011/08-2016/12  香港中文大学  病理解剖及细胞学系   博士

工作经历：

2010/10-2011/07  香港中文大学  病理解剖及细胞学系 研究助理

2016/01-2019/10  香港中文大学  病理解剖及细胞学系 博士后

2020/08-今      中山大学附属第七医院 副研究员 硕士生导师

主要研究方向:

1. 表观遗传修饰在癌症发生发展中作用机制；
2. 肝癌中基因组，转录组，表观遗传组和免疫微环境的异质性；
3. 突变基因与异常表达的蛋白质，非编码RNA等在肝癌发生发展的作用机制及临床应用

荣誉和奖励:

2020/08  中山大学“百人计划”人才

科研论文：

1.  Ding X #, He M #, Chan AW, Song QX, Sze SC, Chen Hui, Man MK, Man K, Chan SL, Lai PB, Wang X, Wong N. (2019). Genomic and Epigenomic Features of Primary and Recurrent Hepatocellular Carcinomas. Gastroenterology 157,1630–1645; (# co-first author)

2.  Chen H #, Gao F #, He M # , Ding X, Wong AM, Sze SC, Yu AC, Sun TT, Chan AW, Wang X, Wong N. (2019). Long-Read RNA Sequencing Identifies Alternative Splice Variants in Hepatocellular Carcinoma and Tumor-Specific Isoforms. Hepatology 70, 1011-1025. (# co-first author)

3.    He M #, Qin H #, Poon TC #, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N. (2015). Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs. Carcinogenesis 36, 1008-1018. (# co-first author)

4.    Leung WK #, He M #, Chan AW, Law PT, Wong N. (2015). Wnt/beta-Catenin activates MiR-183/96/182 expression in hepatocellular carcinoma that promotes cell invasion. Cancer Letters 362, 97-105. (# co-first author)

5.    Lai KP, Chen JW, He M, Ching AK, Lau C, Lai PB, To KF, Wong N. (2014). Overexpression of ZFX confers self-renewal and chemoresistance properties in hepatocellular carcinoma. Int J Cancer 135, 1790-1799.

6.    Lau CC, Sun TT, Ching AK, He M, Li JW, Wong AM, Co NN, Chan AW, Li PS, Lung RW, Tong JH, Lai PB, Chan HL, To KF, Chan TF, Wong N. (2014). Viral-human chimeric transcript predisposes risk to liver cancer development and progression. Cancer Cell 25, 335-349.

7.    Law PT, Qin H, Ching AK, Lai KP, Co NN, He M, Lung RW, Chan AW, Chan TF, Wong N. (2013). Deep sequencing of small RNA transcriptome reveals novel non-coding RNAs in hepatocellular carcinoma. J Hepatol 58, 1165-1173.

8.  Jiang L, Lin C, Song L, Wu J, Chen B, Ying Z, Fang L, Yan X, He M, Li J, Li M. (2012). MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-kappaB/IkappaBalpha negative feedback loop. J Clin Invest 122, 33-47.

9.    Leung WK, Ching AK, Chan AW, Poon TC, He M, Wong AS, To KF, Wong N. (2011). A novel interplay between oncogenic PFTK1 protein kinase and tumor suppressor TAGLN2 in the control of liver cancer cell motility. Oncogene 30, 4464-4475.

10.  Li J, Gong LY, Song LB, Jiang LL, Liu LP, Wu J, Yuan J, Cai JC, He M, Wang L, Zeng M, Cheng SY, Li M (2010). Oncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factor-kappaB Pathway. Am J Pathol 176, 699-709.

11.  Li M, Li J, Ding X, He M, and Cheng SY. (2010). microRNA and cancer. AAPS J 12, 309-317.

个人邮箱:

hemian314@126.com