个人简介:
博士生导师
广东省骨科学重点实验室副主任
广东省医学杰出青年人才
中国老年学和老年医学学会骨质疏松分会创新与转化专委会 常务委员/秘书
国际华人骨研协会(ICMRS)终身会员
中国医师协会骨科医师分会骨科基础工作委员会委员
SICOT中国部骨科基础学会第一届委员会委员
中国生理学会基质生物学分会青年学组委员
中国生物材料学会医用金属材料分会青年工作委员会委员
长期从事骨科基础与临床、骨科生物材料的相关研究工作。2016-2018年在瑞士AO国际骨科内固定研究院从事骨科基础研究2年。作为课题负责人主持包括国家自然科学基金面上项目等骨科退变性疾病、骨修复材料相关课题14项,作为子课题负责人参与国家重点研发计划1项,作为主要研究人员参与了973课题、国家自然科学基金重点项目等骨科基础研究相关课题5项。在上述研究工作积累下,在中山大学附属第七医院建立了完善的动态力学培养系统、类器官骨修复材料制备平台、单细胞测序与分析平台;探索了应激与稳态维持相关基因调控骨形成的基因表达及其表观遗传学变化规律;提出以功能为导向的类器官骨修复材料的构建,并在此过程中发现动态力学能调节其免疫微环境。发表论文近54篇,SCI收录43篇,第一作者或通讯作者27篇。
教育背景:
2009.09-2012.06 中山大学附属第一医院 博士学位
2005.09-2008.06 南通大学医学院 硕士学位
1991.09-1995.06 莱阳卫生学校 医士
教学情况:
博士研究生:王建民 汪文涛 李俊宏
科研工作:
1) 研究方向:
1.动态力学下类器官构建及应用研究
2.干细胞及再生医学,生物材料
3.骨科相关组织器官发育及退变研究(骨、软骨、椎间盘等)
4.骨科基础与临床单细胞测序研究
本研究团队还将与国内外多所知名院校和科研机构如瑞士AO国际内固定研究院、深圳大学、南方科技大学等开展广泛和深入的合作,共同推进课题进展。
2)科研立项:
1. 2021年瑞士AOCMF国际合作项目 The application research of the instructive bone regenerating hydrogel under the dynamic mechanical microenvironment 358万人民币
2. 国家自然科学基金面上项目 动态力学条件下PIEZO1/2介导调节类器官骨修复材料炎性微环境的作用及机制研究 32071351 2021/01-2024/12 61万 在研 主持
3. 深圳市科创委,基础研究,JCYJ20190809142211354,精准仿生类器官骨修复材料的构建及应用基础研究 2020/05-2023/01, 20万元,在研,主持
4. 深圳市科创委国际合作项目 类器官骨修复材料的构建和应用基础研究 GJHZ20180929160004704 2019 2019/09-2021/09 50万 在研 主持
5. 中山大学青年教师重点培育项目 间充质干细胞亚群生物微加工构建类器官骨修复材料 19ykzd05 2019/01-2020/12 30万 在研 主持
6. 国家自然科学基金面上项目 透明质酸活化CD44与HIF-1α信号通路协同促进髓核组织再生的机理 81772400 2018/01-2021/12 55万 在研 主持
7. 国家重点研发计划 华南生物医用材料与植入器械创新示范基地子课题2017YFC1105000 2017/07-2020/12 86.88万 骨干研究人员 在研 主持
8. 广州市产学研协同创新重大专项 基于三维培养的多种间充质干细胞大规模扩增体系建设及应用研究 201604046028 2016/05-2019/04 50万 在研 分题负责人
9. Sino Swiss Science and Technology Cooperation Programme(SSSTC) EG-04-032015 Beta-catenin signaling in intervertebral degeneration disease 2016/01-2018/01 36 万元 结题 主持
10. ARI Project of feasibility the role of LncRNAs in degenerative disc disease and translational research PG108/5 2017/03-2018/02 14万 结题 主持
11. 中山大学附属第七医院启动 关节软骨衰老与退变单细胞图谱演变及机制研究 20万元
12. 广东省自然科学基金 2014A030310466 腰椎间盘退变性疾病生物再生治疗时间窗的研究 2015/01-2018/01 10万元 结题 主持
13. 中国博士后基金特别资助 2014T70826 恒河猴腰椎间盘退变再生治疗时间窗的分子成像量化研究 2014/04-2016/04 15万元 结题 主持
14. 中国博士后基金 2013M531876 终板下骨注射平阳霉素建立恒河猴缺血性椎间盘退变模型 2013/04-2015/11 5万元 结题 主持
15. 华南理工大学开放课题 Epigallocatechin-3-gallate在关节软骨修复过程中的作用于机理研究 1.5万元 2011.09-2013.08结题 主持
3)科研论文(仅第一/通讯):
1. Zhang, P.#, X. Liu#, P. Guo#, X. Li, Z. He, Z. Li, M. J. Stoddart, S. Grad, W. Tian, D. Chen*, X. Zou*, Z. Zhou* and S. Liu (2021). "Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration." Bioactive Materials 6(10): 3097-3108. DOI:10.1016/j.bioactmat.2021.02.024. (IF:14.593)
2. Peng Guo#, Xizhe Liux#, Penghui Zhang#, Zhongyuan He, Zhen Li, Mauro Alini, R. Geoff Richards, Sibylle Grad, Martin J. Stoddart, Guangqiang Zhou, Xuenong Zou, Danny Channy, Wei Tian, Dafu Chen*, Manman Gao*, Zhiyu Zhou*, Shaoyu Liu A single-cell transcriptome of mesenchymal stromal cells to fabricate bioactive hydroxyapatite materials for bone regeneration. Bioactive Materials (accepted)2021 (IF:14.593)
3. Zhou, Zhiyu(#),Jiang, Bo,Zhou, Zhiyang,Pan, Ximin,Sun, Haixing,Huang, Baoding,Liang, Tangzhao,Ringgaard, Steffen,Zou, Xuenong(*),Intervertebral Disk Degeneration: T1 rho MR Imaging of Human and Animal Models,Radiology,2013.8.01,268(2):492~500(IF:11.105)
4. Ma J1, Guo W, Gao M, Huang B, Qi Q, Ling Z, Chen Y, Hu H, Zhou H, Yu F, Chen K, Richards G, Lin J, Zhou Z(*), Xiao D(*), Zou X(*). Biomimetic matrix fabricated by LMP-1 gene-transduced MC3T3-E1 cells for bone regeneration. Biofabrication. 2017 Nov 14;9(4):045010. doi: 10.1088/1758-5090/aa8dd1(IF:9.954)
5. Ma, Junxuan(#),Zhou, Zhiyu(#),Gao, Manman,Yu, Binsheng,Xiao, Deming(*),Zou, Xuenong(*),B¨¹nger, Cody(*),Biosynthesis of Bioadaptive Materials: A Review on Developing Materials Available for Tissue Adaptation,Journal of Materials Science & Technology,Volume 32, Issue 9, September 2016, Pages 810-814 (IF:8.067)
6. Chen, Shaoming#,Gao, Manman#,Zhou, Zhiyu#,Liang, Jiabi,Gong, Ming,Dai, Xuejun,Liang, Tangzhao,Ye, Jiacheng,Wu, Gang,Zou, Lijin,wang yingjun,Zou Xuenong*,Opposite Regulation of Chondrogenesis and Angiogenesis in Cartilage Repair ECM Materials under Hypoxia,Journal of Materials Science & Technology(1005-0302),2016.08.03,32(9):978~985 (IF:8.067)
7. Bao-Liang Li, Xizhe Liu, Manman Gao, Fu Zhang, Xu Chen, Zhongyuan He, Jianmin Wang, Wei Tian, Dafu Chen*, Zhiyu Zhou*, Shaoyu Liu Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model. Oxidative Medicine and Cellular Longevity 2021 (IF:6.453)
8. L. Wen, M. Gao, Z. He, P. Guo, Z. Liu, P. Zhang, F. Zhang, D. Chen, G. Zhou, Z. Zhou, Noggin, an inhibitor of bone morphogenetic protein signaling, antagonizes TGF-β1 in a mouse model of osteoarthritis, Biochem Biophys Res Commun 570 (2021) 199-205. (IF:3.575)
9. S. Cui, Z. Zhou, X. Chen, F. Wei, R.G. Richards, M. Alini, S. Grad, Z. Li, Transcriptional profiling of intervertebral disc in a post-traumatic early degeneration organ culture model, JOR SPINE n/a(n/a) e1146(IF:first year)
10. Shangbin Cui#, Zhiyu Zhou#, Xizhe Liu, R. Geoff Richards, Mauro Alini,Songlin Peng, Shaoyu Liu, Xuenong Zou, Zhen Li, Sibylle Grad* Identification and Characterization of Serum microRNAs as Biomarkers for Human Disc Degeneration: An RNA Sequencing Analysis. diagnostics 2020, 10(12) , 1063(IF:3.706)
11. Zhiyu Zhou, Shangbin Cui, Jie Du, R. Geoff Richards, Mauro Alini, Sibylle Grad, Zhen Li. One Strike Loading Organ Culture Model to Investigate the Post-traumatic Disc Degenerative Condition. J Orthop Translat. 2020 Oct 20;26:141-150. doi: 10.1016/j.jot.2020.08.003. eCollection 2021 Jan. (IF:5.191)
12. Zhiyu Zhou , Stephan Zeiter , Tanja Schmid , Daisuke Sakai , James C. Iatridis , Guangqian Zhou , R. Geoff Richards, Mauro Alini , Sibylle Grad , and Zhen Li Effect of the CCL5-Releasing Fibrin Gel for Intervertebral Disc Regeneration Cartilage 2018 https://doi.org/10.1177/1947603518764263(IF:4.634)
13. Gao MM#, Su QN#, Liang TZ, Ma JX, Liang TZ, Stoddart MJ, Richards RG, Zhou ZY#, Zou NX#1. Transcriptional activation of ENPP1 by osterix in osteoblasts and osteocytes. Eur Cell Mater. 2018 Jul 25;36:1-14. doi: 10.22203/eCM.v036a01. (IF:3.942)
14. Zhiyu Zhou(#),Fuxin Wei(#),Sheng Huang(#),Manman Gao,Haisheng Li,Hans Stødkilde-Jørgensen,Martin Lind,Cody Bünger,Xuenong Zou(*),InVivo Magnetic Resonance Imaging Evaluation of Porous Tantalum Interbody FusionDevices in a Porcine Spinal Arthrodesis Model,Spine,2015.10.1,40(19):1471~8 (IF:3.468)
15. Zhou, Zhiyu(#),Gao, Manman(#),Wei, Fuxin(#),Liang, Jiabi,Deng, Wenbin,Dai, Xuejun,Zhou, Guangqian(*),Zou, Xuenong(*),Shock Absorbing Function Study on Denucleated Intervertebral Disc with or without Hydrogel Injection through Static and Dynamic Biomechanical Tests In Vitro,Biomed Research International,2014.3.5,8(1):72~76 (IF:3.411)
16. Zhou ZhiYu,Zou LiJin,Li HaiSheng,Bunger Cody,Zou XueNong(*),An overview on bone protein extract as the new generation of demineralized bone matrix,Science China Life Sciences,2012.12.01,55(12):1045~1056 (IF:6.038)
17. Zhou, Zhiyang(#),Zhou, Zhiyu(#),Chen, Shaoming(#),Li, Haisheng,Zou, Lijin,Ye, Jiacheng,Ringgaard, Steffen,Bunger, Cody,Zou, Xuenong(*),T1 rho-MR imaging technique to distinguish four-layered zonal structure of articular cartilage for detecting early-onset osteoarthritis,Journal of X-Ray Science and Technology,2012.01.01,20(4):437~446 (IF:1.535)
18. Chen, Da-Fu(#),Zhou, Zhi-Yu(#),Dai, Xue-Jun(#),Gao, Man-Man,Huang, Bao-Ding,Liang, Tang-Zhao,Shi, Rui,Zou, Li-Jin,Li, Hai-Sheng,Bunger, Cody,Tian, Wei(*),Zou, Xue-Nong(*),Time-sequential changes of differentially expressed miRNAs during the process of anterior lumbar interbody fusion using equine bone protein extract, rhBMP-2 and autograft,FRONTIERS OF MATERIALS SCIENCE,2014.3.01,8(1):72~86 (IF:2.765)
19. Fuxin Wei(#),Rui Zhong(#),Zhiyu Zhou(#),Le Wang,Ximin Pan,Shangbin Cui,Xuenong Zou,Manman Gao,Haixing Sun,Wenfang Chen,Shaoyu Liu(*),In vivo experimental intervertebral disc degeneration induced by bleomycin in the rhesus monkey,BMC Musculoskelet Disord,2014.10.9,15(340) (IF:2.362)
20. Fuxin Wei(#),Le Wang(#),Zhiyu Zhou(#),Rui Zhong,Shaoyu Liu(*),Shangbin Cui,Ximin Pan,Manman Gao,Cervical cage without plating in management of type II _ II A Hangman’s fracture combined with intervertebral disc injury,BMC Musculoskeletal Disorders,2015.10.6,16(285) (IF:2.362)
21. Fuxin Wei(#),Ximin Pan(#),Zhiyu Zhou(#),Shangbin Cui,Rui Zhong,Le Wang,Manman Gao,Ningning Chen,Zijian Liang,Xuenong Zou,Sheng Huang,Shaoyu Liu(*),Anterior-only stabilization using cage versus plating with bone autograft for the treatment of type II/IIA Hangman’s fracture combined with intervertebral disc injury,J Orthop Surg Res,2015.3.11,10(33) (IF:2.359)
22. Wei, F(#),Zhou, Z(#),Wang, L(#),Liu, S,Zhong, R,Liu, X,Cui, S,Pan, X,Gao, M,Zhao, Y,Biomechanical evaluation of monosegmental pedicle instrumentation in a calf spine model and the role of fractured vertebrae in screw stability,BMC Vet Res . 2016 Mar 18;12:5,12:57 (IF:2.741)
23. F. Zhang#, S. Wang#, B. Li, W. Tian, Z. Zhou*, S. Liu*, Intradiscal injection for the management of low back pain, JOR SPINE n/a(n/a) e1186. (IF:first year)
24. Jianmin Wang#, Peixuan Zhu#, Ximin Pan, Jun Yang, Shijun Wang, Wentao Wang, Baoliang Li, Zhengya Zhu, Tao Tang, Dafu Chen*, Manman Gao*, Zhiyu Zhou* Correlation between motor behaviour and age-related intervertebral disc degeneration in cynomolgus monkeys JOR SPINE 2021 accepted(IF:first year)
25. Huachuan Wu#, Kuileung Tong#, Xizhe Liu#, Jianfeng Li, Xianlong Li, Manman Gao, Wei Tian, Dafu Chen*, Zhiyu Zhou*, Shaoyu Liu, A comparison between two laminectomy procedures in mouse spinal cord injury on Allen‘s animal model, Journal of Neuroscience Methods 2021 accepted(IF:2.390)
26. 周治宇(#),邹立津,李海声,Cody Bünger,邹学农(*),骨蛋白提取物:新一代基于脱钙骨基质的骨修复材料,中国科学:生命科学,2012.01.01,(12):974~985
27. 梁嘉碧(#),李俊,汪婷,梁雨虹,邹学农,周光前,周治宇(*),原位交联透明质酸水凝胶的制备及体外生物相容性研究,中国修复重建外科杂志,2016.5.01,(06):767~771