个人简介：
中山大学附属第七医院副研究员，硕士生导师，深圳市高层次人才。主要研究方向：新型生物医药设计与抗肿瘤应用及其肿瘤耐药逆转研究。共发表论文20余篇，其中以第一/通讯作者发表研究论文16篇，研究成果主要发表在Molecular Cancer、Advanced Materials、Drug resistance updates、Cancer Letters、ACS Applied Materials & Interfaces、Inorganic Chemistry Frontiers、Chemical Communications等期刊，申请中国发明专利1项并获得授权。目前主持国自然科学基金青年项目、广东省自然科学面上项目1项、深圳市医学研究专项青年项目，深圳市面上项目2项，参与国自然科学基金面上项目1项。
教育背景：
2017/09-2020/06 中山大学 生物无机化学 博士
2014/09-2017/06 湘潭大学 化学生物学 硕士
工作经历：
2024/01-至今 中山大学，附属第七医院，副研究员
2022/10-2023/12 中山大学，附属第七医院，助理研究员
2020/09-2022/09 中山大学，附属第七医院，博士后
主要研究方向:
1. 新型抗肿瘤药物设计与抗肿瘤应用研究
2. 工程化外泌体构建与肿瘤精准治疗研究
3. 微生物耐药与肿瘤多药耐药逆转研究
项目经费
(1)深圳市医学研究专项资金管理委员会，青年项目，2025-01至2027-12，80万元,在研,主持。
(2)深圳市科技创新委员会，面上项目，2024-10至2027-11，30万元,在研，主持。
(3)国家自然科学基金委员会，国家自然科学基金青年项目，2024-01至2026-12，30万元，在研，主持。
(4)国家自然科学基金委员会，面上项目，2023-01至2026-12，53万元，在研，参与。
(5)广东省基础与应用基础研究基金委员会，面上项目，2023-01至2025-12，10万元，在研，主持。
(6)深圳市科技创新委员会，面上项目，2022-10至2025-10，15万元，在研，主持。
(7)广东省消化系统恶性肿瘤防治研究重点实验室2022年度开放基金，5万元，结题，主持。
代表性论文 (1为第一/共同第一作者，*为通讯/共同通讯作者)
(1) Tsz Kin Mak1, Kuan Li1, Zidan Zhao1, Kexin Wang, Leli Zeng, Qilang He, Weiqun Lu, Wei Chen, Yulong He*, Jia Li*, Changhua Zhang*, m6A demethylation of NNMT in CAFs promotes gastric cancer progression by enhancing macrophage M2 polarization, Cancer Letters, 2025, 611: 217422. 中科院一区 (IF=9.1)
(2) Hongfa Wei1, Wenchao Li1, Leli Zeng, Ni Ding, Kuan Li, Hong Yu, Fei Jiang, Haofan Yin, Yu Xia, Cuncan Deng, Nan Cai, Xiancong Chen, Liang Gu, Huanjie Chen, Feiran Zhang*, Yulong He*, Jia Li*, Changhua Zhang*, OLFM4 promotes the progression of intestinal metaplasia through activation of the MYH9/GSK3β/β-catenin pathway, Molecular Cancer, 2024, 23(1): 124. 中科院一区 (IF=27.7)
(3) Cuncan Deng1, Mingyu Huo1, Hongwu Chu1, Xiaomei Zhuang1, Guofei Deng, Wenchao Li, Hongfa Wei, Leli Zeng*, Yulong He, Huashan Liu, Jia Li*, Changhua Zhang*, Hengxing Chen*, Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote
gastric cancer progression, Molecular Cancer, 2024, 23(1): 49. 中科院一区 (IF=27.7)
(4) Jia Li, Zhe-Sheng Chen*, Yihang Pan*, Leli Zeng*. The important role of lactylation in regulating DNA damage repair and tumor chemotherapy resistance, Drug resistance updates: reviews and commentaries in antimicrobial and anticancer chemotherapy, 2024: 101148. 中科院一区 (IF=15.8)
(5) Hengxing Chen1, Yun Li1, Huafu Li1, Xiancong Chen, Huafeng Fu, Deli Mao, Wei Chen, Linxiang Lan, Chunming Wang, Kaishun Hu, Jia Li, Chengming Zhu, Ian Evans, Eddie Cheung, Daning Lu, Yulong He*, Axel Behrens*, Dong Yin*, Changhua Zhang*, NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance, Nature, 2024, 631(8021): 663-669. 中科院一区 (IF=50.5)
(6) Huan Yang, Yuhong Liu, Jia Li*, Yulong He*, Leli Zeng*, Yihang Pan*, The Role of Organoid‐Based Drug Sensitivity Testing in Clinical Cancer Therapy, Organ Medicine, 2024, 1(2): 49-50.
(7) Leli Zeng1, B. H. Jaswanth Gowda1, Mohammed Gulzar Ahmed, Mohammed A. S. Abourehab, Zhe-Sheng Chen, Changhua Zhang*, Jia Li*, Prashant Kesharwani*, Advancements in nanoparticle-based treatment approaches for skin cancer therapy, Molecular Cancer, 2023, 22(1):0-10. 中科院一区 (IF=27.7)
(8) Jia Li1, Leli Zeng1*, Zheng Wang, Hengxing Chen, Shuo Fang, Jinquan Wang, Chao-Yun Cai, Enming Xing, Xinxing Liao, Zhi-Wei Li, Charles R. Ashby Jr, Zhe-Sheng Chen*, Hui Chao*, Yihang Pan*, Cycloruthenated Self-Assembly with Metabolic Inhibition to Efficiently Overcome Multidrug Resistance in Cancers, Advanced Materials, 2022, 34(1): 0-2100245. 中科院一区 (IF=27.4)
(9) Johannes Karges1, Jia Li1, Leli Zeng, Hui Chao*, Gilles Gasser*, Polymeric Encapsulation of a Ruthenium Polypyridine Complex for Tumor Targeted One- and Two-Photon Photodynamic Therapy, ACS Applied Materials & Interfaces, 2020, 12(49): 54433-54444. 中科院一区 (IF=8.5)
(10) Jia Li, Hongmin Chen, Leli Zeng, Thomas W. Rees, Kai Xiong, Yu Chen*, Liangnian Ji, Hui Chao*, Mitochondria- targeting cyclometalated iridium(III) complexes for tumor hypoxic imaging and therapy, Inorganic Chemistry Frontiers, 2019, 6(4): 1003-1010. 中科院一区 (IF=6.1)
(11) Jia Li, Leli Zeng, Kai Xiong, Thomas W. Rees, Chengzhi Jin, Weijun Wu, Yu Chen*, Liangnian Ji, Hui Chao*, A biotinylated ruthenium(ii) photosensitizer for tumor-targeted twophoton photodynamic therapy, Chemical Communications, 2019, 55(73): 10972-10975. 中科院二区 (IF=4.3)
(12) Leli Zeng 1, Jia Li 1, Chen Zhang, Yun-Kai Zhang, Wei Zhang, Juanjuan Huang, Charles R. Ashby Jr, Zhe-Sheng Chen*, Hui Chao*, An organoruthenium complex overcomes ABCG2- mediated multidrug resistance via multiple mechanisms, Chemical Communications, 2019, 55(26): 3833-3836. 中科院二区(IF=4.3)
个人邮箱:
lijia88@mail.sysu.edu.cn