个人简介：
现任中山大学附属第七医院副研究员，硕士生导师，中山大学“百人计划”海外高层次引进人才，深圳市海外高层次C类人才。博士毕业于香港大学病理系。主持国家级项目2项、省级项目2项以及深圳市科创局项目和深圳医学科学院项目各一项。并以核心成员参与香港医疗卫生研究基金两项、深圳市重点项目一项。以通讯作者及第一作者身份在国际知名学术期刊包括Advanced Sciences, Elife, Theranostics 和Cell Death & Diseases等期刊发表多篇论文。担任Advanced Sciences, Cancer Letter, Cancer Communications 等杂志审稿人。
教育背景：
2004/09-2009/07 中山大学, 预防医学 学士
2010/01-2012/05 圣约翰大学, 毒理学 硕士
2012/09-2017/02 香港大学 病理学 博士
工作经历：
2017/02-2021/01 香港大学，病理系 博士后
2021/02-今 中山大学附属第七医院 副研究员 硕士生导师
主要研究方向:
用肿瘤临床样本、类器官和人源化肿瘤动物模型，从事以下研究：
1. 肿瘤干细胞的调控机制研究
2. 肿瘤耐药机制及治疗靶点研究
3. 利用肺癌类器官模型进行肿瘤微环境及肿瘤免疫相关研究
4. 肿瘤细胞外囊泡在肿瘤发生发展中的作用机制研究
荣誉和奖励:
2021/02 中山大学人才
2018/02 香港大学李嘉诚医学院病理系 “Chan To Haan Prize for Research Postgraduate Student in Pathology”奖金 1万港币（2018年度病理系2位获奖者之一）
2014/04、2016/04、 2018/04、 2020/11 香港大学海外学术会议基金
2014/07 香港大学李嘉诚医学院病理系最佳研究生学术报告奖。 （2014年度唯一获奖者）
2014/06 香港大学李嘉诚医学院奖学金 “The YS and Christabel Lung Postgraduate Scholarship” 2.1万港币
2012/05 圣约翰大学 “Certificate of Academic excellence”（2012年度毒理系唯一获奖者）
科研论文：
1. Jia Liu; Jing Li; Jian Luo; Yuchen Jiang; Huiyi Hu; Leqing Zhu; Yun Li; Zhi-Jie Xiao;
Therapeutic potential of targeting MASTL in lung adenocarcinoma, Scientific Reports, 2026, 202616:6998(2026 16:6998)
2. Huiyi Hu #, Yuanqun Chen #, Bo Hong # , Jia Liu, Yuchen Jiang 1, Zhiying Yu, Zhi-Jie Xiao*, Jing Li*. A four-gene signature identified by integrated transcriptomic analysis for differential diagnosis and prognosis of uterine smooth muscle tumors. Front Oncol. 2025 Aug 4:15:1591875. doi: 10.3389/fonc.2025.1591875. eCollection 2025.
3. Ziheng Wu#, Meilin Luo#, Huiyi Hu, Zhijun Jiang, Yinan Lu & Zhi-Jie Xiao. Hidden forces: the impact of cancer-associated fibroblasts on non-small cell lung cancer development and therapy. J Transl Med. 2025 Jul 25;23(1):830. doi: 10.1186/s12967-025-06791-x.
4. Zhi-Jie Xiao#*, Si-Qi Wang#, Jun-Jiang Chen#, Yun Li, Yuchen Jiang, Vicky Pui-Chi Tin, Jia Liu, Huiyi Hu, Maria Pik Wong, Yihang Pan*, Judy Wai Ping Yam*. The Dual Role of the NFATc2/galectin-9 Axis in Modulating Tumor-Initiating Cell Phenotypes and Immune Suppression in Lung Adenocarcinoma. Advanced Science, 2024, Mar; 2306059.
5. Si-Qi Wang#; Jun-Jiang Chen#; Yuchen Jiang; Zi-Ning Lei; Ye Chun Ruan; Yihang Pan; Judy Wai Ping Yam; Maria Pik Wong*; Zhi-Jie Xiao*. Targeting GSTP1 as Therapeutic Strategy against Lung Adenocarcinoma Stemness and Resistance to Tyrosine Kinase Inhibitors. Advanced Science, 2023 Mar;10(7):e2205262. doi: 10.1002/advs.202205262.
6. Yue Yao#, Yi Xu#, Liang Yu, Ting-Mao Xue, Zhi-Jie Xiao, Pui-Chi Tin, Hiu-Ling Fung, HoiTang Ma, Jing-Ping Yun , Judy Wai Ping Yam. NHE7 upregulation potentiates the uptake of small extracellular vesicles by macropinocytosis in hepatocellular carcinoma. Cancer Communications 2023, 44(2):251-272.
7. Samuel Wan Ki Wong, Sze Keong Tey, Xiaowen Mao, Hiu Ling Fung, Zhi-Jie Xiao, Danny Ka Ho Wong, Lung-Yi Mak, Man-Fung Yuen, Irene Oi-Lin Ng, Jing Ping Yun, Yi Gao, Judy Wai Ping Yam. Small extracellular vesicle-derived vWF induces a positive feedback loop between tumour and endothelial cells to promote angiogenesis and metastasis in hepatocellular carcinoma. Advanced Science 2023, 10(26):e2302677
8. Zhijie Xiao, Charlie Lot Sum Yeung, Judy Wai Ping Yam, Xiaowen Mao. An update on the role of complement in hepatocellular carcinoma. Front Immunol. 2022 Oct 19;13:1007382. doi: 10.3389/fimmu.2022.1007382. eCollection 2022.
9. Si-Qi Wang, Jing Liu, Jing Qin, Yun Zhu, Vicky Pui-Chi Tin, Judy Wai Ping Yam, Maria Pik Wong, Zhi-Jie Xiao. CAMK2A supported Tumor Initiating Cells of Lung Adenocarcinoma by upregulating SOX2 through EZH2 Phosphorylation. Cell Death & Disease. 2020 Jun 1;11(6):410. doi: 10.1038/s41419-020-2553-6. （Corresponding author）
10. Jun-Jiang Chen*, Zhi-Jie Xiao*, Xiaojing Meng, Yan Wang, Mei Kuen Yu, Wen Qing Huang, Xiao Sun, Hao Chen, Yong-Gang Duan, Maria Pik Wong, Hsiao Chang Chan, Fei Zou, Ye Chun Ruan. MRP4 sustains Wnt/β-catenin signaling for pregnancy, endometriosis and endometrial cancer. Theranostics 2019; 9(17):5049-5064. doi:10.7150/thno.32097 (*Co-first author)
11. Zhi-Jie Xiao, Jing Liu, Si-Qi Wang, Yun Zhu, Xu-Yuan Gao, Vicky Pui-Chi Tin, Jing Qin, Jun-Wen Wang, Maria Pik Wong. NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma. Elife. 2017 Jul 24;6. pii: e26733. doi: 10.7554/eLife.26733.
个人邮箱:
xiaozhj5@mail.sysu.edu.cn, zxiaozhijie@163.com