跳转到主要内容
叶丽平
博士生导师、副研究员

个人简介: 

叶丽平,中山大学博士生导师,副研究员;深圳市高层次专业人才,深圳市优青。主要从事肿瘤侵袭转移以及耐药的分子机制研究,以通讯/第一作者发表SCI论文十余篇:包括EMBO Mol Med, Theranostics, Cancer Let, Cell Death Dis等学术期刊。作为负责人主持国家自然科学基金等科研项目,作为主要参与人参加国家自然科学基金多项,包括重点项目、重大研究计划项目、面上项目等。

本课题组常年招收2名博士后,研究方向一致的有意者可发送简历及近年代表作至邮箱:yelp5@mail.sysu.edu.cn

 

教育背景:

2014/09-2017/06,中山大学肿瘤防治中心,基础医学,博士

2010/09-2013/06,深圳大学,生物医学工程,硕士

2006/09-2010/06,南方医科大学,生物医学工程,学士

工作经历:

2020/01-至今,中山大学附属第七医院,科研中心,副研究员

2019/11-2019/12,中山大学附属第七医院,科研中心,特聘副研究员

2017/07-2019/10,中山大学肿瘤防治中心,肿瘤学博士后

2013/07-2014/07,中国科学院深圳先进技术研究院,研究助理

 

研究方向:

1. 肿瘤发病机制及诊断标记物:乳腺癌和前列腺癌肿瘤标志物研究

2. 肿瘤耐药机制及治疗靶点研究:乳腺癌内分泌治疗耐药及前列腺癌去势抵抗机制研究

3. 肿瘤骨转移微环境研究:肿瘤细胞如何调控自身与骨转移微环境相互作用的机制研究

 

主持项目:

1. 国家自然科学基金面上项目(2025.01-2028.1249万)

2. 广东省自然科学基金面上项目(2025.01-2027.1210万)

3. 国家自然科学基金面上项目(2021.01-2024.12,结题)

4. 广东省自然科学基金面上项目(2022.01-2024.12,结题)

5. 深圳市科技创新委员会优秀创新人才项目(优青)(2022.4--2025.4,结题)

6. 深圳市科技创新委员会基础研究面上项目(2021.10-2024.10,结题)

7. 中山大学附属第七医院启动基金(2019.11-2022.11,结题)

8. 国家自然科学基金青年科学基金项目(2019.01-2021.12,结题)

9. 国博士后科学基金面上项目(2017.11-2019.10,结题)

 

发表论文:

1. Q Li#, C Li#, Y Zhang#, Z Zheng, Y Wang, Y Yang, Q Zhu, R Wang, W Xu, C Zhu, Q Tian*, M Wang*, L Ye*. The tumor suppressor SALL2 opposes chemotherapeutic resistance in breast cancer. Mol Cell Biochem. 2025. 480(5): 2971-2983.

2. Chenxin Li#, Yuhao Zhang#, Yun Wang#, Jing Ouyang, Yingqian Yang, Qingqing Zhu, Yingsi Lu, Tingting Kang, Yan Li, Ming Xia, Jinrun Chen, Qiji Li*, Chengming Zhu*, Liping Ye*. RNA-binding protein LSM7 facilitates breast cancer metastasis through mediating alternative splicing of CD44. Life Sciences. 2024.

3. Jing Ouyang, Shuang Hu, Qingqing Zhu, Chenxin Li, Tingting Kang, Wenlin Xie, Yun Wang, Yan Li, Yingsi Lu, Jinhua Qi, Ming Xia, Jinrun Chen, Yingqian Yang, Yazhou Sun, Tianshun Gao, Liping Ye*, Qian Liang*, and Yihang Pan*, Chengming Zhu*. RANKL/RANK signaling recruits Tregs via the CCL20-CCR6 pathway and promotes stemness and metastasis in colorectal cancer. Cell Death Dis. 2024, 15(6):437.  

4. Hu S, Ouyang J, Zheng G, Lu Y, Zhu Q, Wang B*, Ye L*, Zhu C*: Identification of mutant p53-specific proteins interaction network using TurboID-based proximity labeling. Biochem Biophys Res Co. 2022, 615:163-171.

5. Li Q#, Wang M#, Zeng L#, Guo W, Xu Y, Li C, Lai Y, Ye L*, Peng X*. Deletion of Wild-type p53 Facilitates Bone Metastatic Function by Blocking the AIP4 Mediated Ligand-Induced Degradation of CXCR4. Frontiers in Pharmacology. 2022, 12.

6. Li Q, Wang M, Hu Y, Zhao E, Li J, Ren L, Wang M, Xu Y, Liang Q, Zhang D, Lai Y, Liu S, Peng X, Zhu C*, Ye L*. MYBL2 disrupts the Hippo-YAP pathway and confers castration resistance and metastatic potential in prostate cancer. Theranostics. (2021) 11 (12): 5794-5812.

7. Liang Q#, Wang Y#, Lu Y, Zhu Q, Xie W, Tang N, Huang L, An T, Zhang D, Yan A, Liu S, Ye L*, Zhu C*. RANK promotes colorectal cancer migration and invasion by activating the Ca2+-calcineurin/NFATC1-ACP5 axis. Cell Death & Disease. (2021) 12: 336.

8. Ye L#, Lin C#, Wang X#, Li Q#, Li Y, Wang M, Zhao Z, Wu X, Shi D, Xiao Y, Ren L, Jian Y, Yang M, Ou R, Deng G, Ouyang Y, Chen X, Li J, Song L. Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer. EMBO Molecular Medicine. (2019) e10638.  

9. Ye L#, Li F#, Song Y#, Yu D, Xiong Z, Li Y, Shi T, Yuan Z, Lin C, Wu X, Ren L, Li X, Song L. Overexpression of CDCA7 predicts poor prognosis and induces EZH2-mediated progression of triple-negative breast cancer. Int J Cancer. 2018; 143: 2602-2613.

10. Liu J#, Ye L#, Li Q#, Wu X, Wang B, Ouyang Y, Yuan Z, Li J, Lin C. Synaptopodin-2 suppresses metastasis of triple-negative breast cancer via inhibition of YAP/TAZ activity. J Pathol. 2018; 244: 71-83.

11. Xiong Z#, Ye L#, Zhenyu H, Li F, Xiong Y, Lin C, Wu X, Deng G, Shi W, Song L, Yuan Z, Wang X. ANP32E induces tumorigenesis of triple-negative breast cancer cells by upregulating E2F1. Mol Oncol. 2018; 12: 896-912.

12. Li Q#, Ye L#, Xin Z#, Wang M, Lin C, Huang S, Guo W, Lai Y, Du H, Li J, Song L, Peng X. FZD8, a target of p53, promotes bone metastasis in prostate cancer by activating canonical Wnt/beta-catenin signaling. Cancer Lett. 2017, 402:166-176.

13.Li Q#, Ye L#, Guo W, Wang M, Huang S, Peng X. PHF21B overexpression promotes cancer stem cell-like traits in prostate cancer cells by activating the Wnt/beta-catenin signaling pathway. J Exp Clin Cancer Res. 2017, 36(1):85.

14. Li Q#, Ye L#, Guo W, Wang M, Huang S, Peng X. Overexpression of TACC3 is correlated with tumor aggressiveness and poor prognosis in prostate cancer. Biochem Biophys Res Co. 2017, 486(4):872-878.

出诊信息