个人简介：
中山大学附属第七医院副研究员，硕士生导师。2021年获得中山大学肿瘤学博士学位，并于2021/07-2023/11在中山大学附属第一医院进行博士后研究工作。2024年1月通过博士后转聘副研究员加入中山大学附属第七医院。目前主持国自然青年科学基金1项，参与国自然面上科学基金和科技部重点研发项目各1项。先后在《Science Immunology》, 《Nature Chemical Biology》, 《Nature Communications》, 《Cancer Communications》, 《Advanced Science》等高影响因子学术期刊发表多篇学术成果。
教育工作经历：
2024/01-至今 中山大学附属第七医院 副研究员
2021/07-2023/11 中山大学附属第一医院 临床博士后
2016/09-2021/06 中山大学肿瘤防治中心 肿瘤学 医学博士
2011/09-2016/06 中山大学中山医学院 临床医学 医学学士
主要研究方向:
1. T细胞抗肿瘤免疫功能关键调控靶点鉴定及免疫治疗技术开发。
2. 抑制性肿瘤免疫微环境形成机制及干预措施。
3. 恶性肿瘤发生发展新机制及治疗策略。
经费项目
1. 国家自然科学基金青年项目（2024-01至2025-12，在研，主持）；
2. 国家自然科学基金面上项目（2022-01至2025-12，在研，参与）；
3. 国家重点研发计划（2018-05至2022-12，结题，参与）。
代表论文 (*为第一/共同第一作者，#为通讯/共同通讯作者)：
1. Jie-Feng Yang*, Xudong Xing*, Li Luo*, Xin-Wei Zhou*, Jian-Xiong Feng, Kang-Bo Huang, Huashan Liu, Shanzhao Jin, Yi-Na Liu, Shi-Hui Zhang, Yi-Hui Pan, Bing Yu, Jin-Yu Yang, Yu-Lu Cao, Yun Cao, Cliff Y. Yang, Yuan Wang, Yuxia Zhang, Jiang Li, Xiaojun Xia, Tiebang Kang, Rui-Hua Xu, Ping Lan, Jun-Hang Luo, Hui Han#, Fan Bai#, Song Gao#. Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors. Science Immunology, 2023, 8(87): 0-eabq2424.
2. Jiefeng Yang*, Li Luo*, Chongyu Zhao*, Xiyuan Li*, Zimo Wang, Ziwei Zeng, Xin Yang, Xiaobin Zheng, Haiqing Jie, Liang Kang, Shujuan Li, Shuang Liu#, Chi Zhou#, Huashan Liu#. A Positive Feedback Loop between Inactive VHL-Triggered Histone Lactylation and PDGFRβ Signaling Drives Clear Cell Renal Cell Carcinoma Progression. Int J Biol Sci, 2022, 18(8): 3470-3483.
3. Li Luo*, Denghui Wei*, Yihui Pan*, Qiu-Xia Wang, Jian-Xiong Feng, Bing Yu, Tiebang Kang, Junhang Luo#, Jiefeng Yang#, Song Gao#. MFN2 suppresses clear cell renal cell carcinoma progression by modulating mitochondria-dependent dephosphorylation of EGFR. Cancer Communications, 2023, 43(7): 808-833.
4. Yihui Pan*, Guannan Shu*, Liangmin Fu*, Kangbo Huang*, Xinwei Zhou*, Chengpeng Gui, Huashan Liu, Xiaohan Jin, Minyu Chen, Pengju Li, Junjie Cen, Zihao Feng, Jun Lu, Zhenhua Chen, Jiaying Li, Quanhui Xu, Yinghan Wang, Hui Liang, Zhu Wang, Qiong Deng, Wei Chen, Junhang Luo#, Jiefeng Yang#, Jiaxing Zhang#, Jinhuan Wei#. EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1. Advanced Science, 2023, 10(11): 0-e2206792.
5. Yi-Na Liu*, Jie-Feng Yang*, Dai-Jia Huang*, Huan-He Ni, Chuan-Xia Zhang, Lin Zhang, Jia He, Jia-Mei Gu, Hong-Xia Chen, Hai-Qiang Mai, Qiu-Yan Chen, Xiao-Shi Zhang, Song Gao#, Jiang Li#. Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways. Frontiers in Immunology, 2020, 11(1906).
6. Jingtao Chen*, Jiefeng Yang*, Huan Li*, Zhongyuan Yang, Xing Zhang, Xiyuan Li, Jia Wang, Ying Zhang, Shuwei Chen#, Ming Song#. Single-cell transcriptomics reveal the intratumoral landscape of infiltrated T-cell subpopulations in oral squamous cell carcinoma. Molecular Oncology, 2021 Apr;15(4):866-886.
7. Yingjie Guo*, Huan Zhang*, Chen Yan, Birong Shen*, Yue Zhang, Xiangyang Guo, Sha Sun, Fan Yu, Jiayun Yan, Ronghe Liu, Qianping Zhang, Di Zhang, Haiyang Liu, Yang Liu, Yaoyao Zhang, Wenlei Li, Jiangyu Qin, He Lv, Zhaoxia Wang, Yun Yuan, Jie-Feng Yang, Ya-Ting Zhong, Song Gao, Bing Zhou, Lei Liu, Deling Kong, Xiaojiang Hao#, Junjie Hu#, Quan Chen#. Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction. Nature Chemical Biology, 2023 Apr;19(4):468-477.
8. Yu-Jie Li*, Yu-Lu Cao*, Jian-Xiong Feng*, Yuanbo Qi, Shuxia Meng, Jie-Feng Yang, Ya-Ting Zhong, Sisi Kang, Xiaoxue Chen, Lan Lan, Li Luo, Bing Yu, Shoudeng Chen, David C Chan, Junjie Hu, Song Gao#. Structural insights of human mitofusin-2 into mitochondrial fusion and CMT2A onset. Nature Communications, 2019 Oct 29;10(1):4914.
个人邮箱:
yangjf28@mail.sysu.edu.cn