个人简介：

       现任中山大学附属第七医院副研究员，硕士生导师，中山大学高层次引进人才。于2016年获得南方医科大学病理生理学专业博士。曾于2013-2017年在美国University of Pittsburgh外科学系先后任Visiting Scholar和Research Associate，并于2017-2020年在美国Johns Hopkins University神经学系任博士后。目前主要研究方向包括：1、细胞外囊泡调控阿尔兹海默症的发生发展机制研究；2、神经退行性疾病中，细胞外囊泡与细胞死亡在其中发挥作用的分子机制研究；3、发掘以细胞外囊泡为载体的相关疾病的新型生物标记物。以第一作者/通讯作者发表SCI论文14篇，包括Journal of Extracellular Vesicles, Cell Communication and Signaling, Ageing Research Reviews, Cell Death & Differentiation, Clinical and Translational Medicine等国际知名学术期刊。曾荣获国际细胞外囊泡协会2019年会的青年研究员奖（ISEV2019 Young Investigator Award）。目前主持国家自然科学基金青年项目、广东省自然面上项目、深圳市科创委面上项目等。

教育背景：

2011.09－2016.07，南方医科大学，病理生理学，博士 

2006.09－2011.07，广州中医药大学，中医学，学士

研究工作经历：

2020.11－至今，中山大学附属第七医院，科研中心，副研究员

2017.11－2020.10，Johns Hopkins University，Post-Doctoral Fellow      

2015.10－2017.10，University of Pittsburgh，Research Associate        

2013.05－2015.09，University of Pittsburgh，Visiting Scholar          

研究方向：

1、细胞外囊泡调控阿尔兹海默症的发生发展机制研究

2、神经退行性疾病中，细胞外囊泡与细胞死亡在其中发挥作用的分子机制研究

3、发掘以细胞外囊泡为载体的相关疾病的新型生物标记物

科研论文：

1. Sitong Liu*, Aitong Feng*, Zhigang Li#. Neuron-Derived Extracellular Vesicles: Emerging Regulators in Central Nervous System Disease Progression. Molecular Neurobiology. 2025 May 6. doi: 10.1007/s12035-025-05010-4.

2. Yongbing Qian*, Xiaoning Hong*, Yang Yu*, Cong Du*, Jing Li, Jiaying Yu, Wenjun Xiao, Chen Chen, Defa Huang, Tianyu Zhong, Jiang Li, Xi Xiang#, Zhigang Li#. Characterization and functional analysis of eccDNA discovered from circulating extracellular vesicles in liver failure. Clinical and Translational Medicine. 2024 Oct;14(10):e70059. doi: 10.1002/ctm2.70059.

3. Yi Zhou*, Chuhan Na*, Zhigang Li#. Novel insights into immune cells modulation of tumor resistance. Critical Reviews in Oncology/Hematology. 2024 Jul 20:202:104457. doi: 10.1016/j.critrevonc.2024.104457.

4. Zhixin Ma*, Yu Sun*, Yang Yu, Wenjun Xiao, Zhijie Xiao, Tianyu Zhong, Xi Xiang, Zhigang Li#. Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis. Cell Communication and Signaling. 2024 May 27;22(1):295. doi: 10.1186/s12964-024-01669-9.

5. Yang Yu*, Ran Chen*, Kaiyue Mao, Maoyan Deng, Zhigang Li#. The Role of Glial Cells in Synaptic Dysfunction: Insights into Alzheimer's Disease Mechanisms. Aging and Disease 2024 Apr 1;15(2):459-479. doi: 10.14336/AD.2023.0718.

6. Yu Sun*, Wenjun Xiao*, Yang Yu, Yuchen Jiang, Zhijie Xiao, Defa Huang, Tianyu Zhong, Jiang Li, Xi Xiang, Yulong He#, Zhigang Li#. Colorectal cancer-derived extracellular vesicles containing HSP70 enhance macrophage phagocytosis by up-regulating MARCO expression. Experimental Cell Research 2023 May 15;426(2):113565. doi: 10.1016/j.yexcr.2023.113565.

7. Biao Li, Zhixin Ma, Zhigang Li#. A novel regulator in Alzheimer's disease progression: The astrocyte-derived extracellular vesicles. Ageing Research Reviews. 2023 Feb 2;86:101871. doi: 10.1016/j.arr.2023.101871.

8. Siqi Wang*, Jiaxin Sun*, Raha M. Dastgheyb, Zhigang Li#. Tumor-derived extracellular vesicles modulate innate immune responses to affect tumor progression. Frontiers in Immunology, 2022 Nov 2;13:1045624. doi: 10.3389/fimmu.2022.1045624.

9. Zhigang Li, Mohammed Moniruzzaman, Raha M. Dastgheyb, Seung-Wan Yoo, Meina Wang, Hongbo Hao, Jia Liu, Patrizia Casaccia, Carlos Nogueras-Ortiz, Dimitrios Kapogiannis, Barbara S. Slusher, Norman J. Haughey. Astrocytes deliver CK1 to neurons via extracellular vesicles in response to inflammation promoting the translation and amyloidogenic processing of APP. Journal of Extracellular Vesicles, 2020; 10(2):e12035.

10. Zhigang Li, Melanie J. Scott, Erica K. Fan, Yuehua Li, Jinghua Liu, Guozhi Xiao, Song Li, Timothy R. Billiar, Mark A. Wilson, Yong Jiang and Jie Fan. Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death & Differentiation. 2016 Sep 1;23(9):1428-47.

11. Zhigang Li, Erica K. Fan, Jinghua Liu, Melanie J. Scott, Yuehua Li, Song Li, Wen Xie, Timothy R. Billiar, Mark A. Wilson, Yong Jiang, Ping Wang, and Jie Fan. Cold-Inducible RNA-Binding Protein through TLR4 Signaling Induces Mitochondrial DNA Fragmentation and Regulates Macrophage Cell Death after Trauma. Cell Death & Disease. 2017 May 11;8(5):e2775. (2017) 8, e2775; doi:10.1038/cddis.2017.187.

12. Zhigang Li, Melanie J. Scott, Tomasz Brzóska, Prithu Sundd, Yue-Hua Li, Timothy R. Billiar, Mark A. Wilson, Ping Wang, and Jie Fan. Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages. Military Medical Research. 2018 Jul 30;5(1):24. doi: 10.1186/s40779-018-0173-6.

13. Zhigang Li, Yang Jiao, Erica K. Fan, Melanie J. Scott, Yuehua Li, Song Li, Timothy R. Billiar, Mark A. Wilson, Xueyin Shi, and Jie Fan. Aging-Impaired Filamentous Actin Polymerization Signaling Reduces Alveolar Macrophage Phagocytosis of Bacteria. The Journal of Immunology. 2017 Nov 1;199(9):3176-3186. 

14. Yang Jiao*, Zhigang Li*, Patricia A. Loughran, Erica K. Fan, Melanie J. Scott, Yuehua Li, Timothy R. Billiar, Mark A. Wilson, Xueyin Shi, and Jie Fan. Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock. Journal of Leukocyte Biology. 2018 Feb;103(2):175-183. (*co-first author).

个人邮箱：

lizhg25@mail.sysu.edu.cn