个人简介：

   现任中山大学附属第七医院副研究员，博士生导师。于2016年获得南方医科大学病理生理学专业博士。曾于2013-2017年在美国University of Pittsburgh外科学系先后任Visiting Scholar和Research Associate，并于2017-2020年在美国Johns Hopkins University神经学系任博士后。以第一作者/通讯作者发表SCI论文15篇，包括Journal of Extracellular Vesicles, Journal of Neuroinflammation, Cell Communication and Signaling, Ageing Research Reviews, Cell Death & Differentiation, Clinical and Translational Medicine等国际知名学术期刊。主持国家自然科学基金、广东省自然面上项目、深圳市医学研究专项资金SMART、深圳市科创委面上项目等。曾荣获国际细胞外囊泡协会2019年会的青年研究员奖（ISEV2019 Young Investigator Award）、中山大学附属第七医院2024年度“杰出教学奖”等。

教育背景：

2011.09－2016.07，南方医科大学，医学博士 

2006.09－2011.07，广州中医药大学，医学学士

研究工作经历：

2020.11－至今，中山大学附属第七医院，科研中心，副研究员

2017.11－2020.10，Johns Hopkins University，Post-Doctoral Fellow      

2015.10－2017.10，University of Pittsburgh，Research Associate        

2013.05－2015.09，University of Pittsburgh，Visiting Scholar         

研究方向：

1、细胞外囊泡调控阿尔兹海默症的发生发展机制研究

2、神经退行性疾病中，细胞外囊泡与细胞死亡在其中发挥作用的分子机制研究

3、发掘以细胞外囊泡为载体的相关疾病的新型生物标记物

科研论文：

1. Yang Yu, Zhixin Ma, Taixu Li, Wenjun Xiao, Zhigang Li*. Neuronal Extracellular Vesicles Carrying APOE Downregulate Filament Actin Polymerization Signaling to Inhibit Synapse Formation in Alzheimer’s Disease. Journal of Extracellular Vesicles. 2026;15(3):e70248. doi:  10.1002/jev2.70248. 
2. Yang Yu^#, Wenjun Xiao^#, Zhixin Ma, Xiaomei Yi, Tianyu Zhong, Zhigang Li*. Circulatory extracellular vesicles transport complement C1q for promoting neuronal amyloid-β production in Alzheimer’s disease. Journal of Neuroinflammation. 2025 Aug 29;22(1):209. doi: 10.1186/s12974-025-03528-x.
3. Sitong Liu^#, Aitong Feng^#, Zhigang Li*. Neuron-Derived Extracellular Vesicles: Emerging Regulators in Central Nervous System Disease Progression. Molecular Neurobiology. 2025 Nov;62(11):14585-14612.
4. Yongbing Qian^#, Xiaoning Hong^#, Yang Yu^#, Cong Du^#, Jing Li, Jiaying Yu, Wenjun Xiao, Chen Chen, Defa Huang, Tianyu Zhong, Jiang Li, Xi Xiang*, Zhigang Li*. Characterization and functional analysis of extrachromosomal circular DNA discovered from circulating extracellular vesicles in liver failure. Clinical and Translational Medicine. 2024 Oct;14(10):e70059. doi: 10.1002/ctm2.70059 
5. Yi Zhou^#, Chuhan Na^#, Zhigang Li*. Novel insights into immune cells modulation of tumor resistance. Critical Reviews in Oncology/Hematology. 2024 Jul 20:202:104457. doi: 10.1016/j.critrevonc.2024.104457
6. Zhixin Ma^#, Yu Sun^#, Yang Yu, Wenjun Xiao, Zhijie Xiao, Tianyu Zhong, Xi Xiang, Zhigang Li*. Extracellular vesicles containing MFGE8 from colorectal cancer facilitate macrophage efferocytosis. Cell Communication and Signaling. 2024 May 27;22(1):295. doi: 10.1186/s12964-024-01669-9.
7. Yang Yu^#, Ran Chen^#, Kaiyue Mao, Maoyan Deng, Zhigang Li*. The Role of Glial Cells in Synaptic Dysfunction: Insights into Alzheimer's Disease Mechanisms. Aging and Disease 2024 Apr 1;15(2):459-479. doi: 10.14336/AD.2023.0718. 
    
8. Biao Li, Zhixin Ma, Zhigang Li*. A novel regulator in Alzheimer's disease progression: The astrocyte-derived extracellular vesicles. Ageing Research Reviews. 2023 Feb 2;86:101871. doi: 10.1016/j.arr.2023.101871.
9. Yu Sun^#, Wenjun Xiao^#, Yang Yu, Yuchen Jiang, Zhijie Xiao, Defa Huang, Tianyu Zhong, Jiang Li, Xi Xiang, Yulong He*, Zhigang Li*. Colorectal cancer-derived extracellular vesicles containing HSP70 enhance macrophage phagocytosis by up-regulating MARCO expression. Experimental Cell Research 2023 May 15;426(2):113565. doi: 10.1016/j.yexcr.2023.113565.
10. Siqi Wang^#, Jiaxin Sun^#, Raha M. Dastgheyb, Zhigang Li*. Tumor-derived extracellular vesicles modulate innate immune responses to affect tumor progression. Frontiers in Immunology, 2022 Nov 2;13:1045624. doi: 10.3389/fimmu.2022.1045624.
     
11. Zhigang Li, Mohammed Moniruzzaman, Raha M. Dastgheyb, Seung-Wan Yoo, Meina Wang, Hongbo Hao, Jia Liu, Patrizia Casaccia, Carlos Nogueras-Ortiz, Dimitrios Kapogiannis, Barbara S. Slusher, Norman J. Haughey*. Astrocytes deliver CK1 to neurons via extracellular vesicles in response to inflammation promoting the translation and amyloidogenic processing of APP. Journal of Extracellular Vesicles, 2020 Dec 31; 10(2):e12035. doi: 10.1002/jev2.12035.
     
12. Zhigang Li, Melanie J. Scott, Erica K. Fan, Yuehua Li, Jinghua Liu, Guozhi Xiao, Song Li, Timothy R. Billiar, Mark A. Wilson, Yong Jiang*, Jie Fan*. Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death & Differentiation. 2016 Sep 1;23(9):1428-47
     
13. Zhigang Li, Erica K. Fan, Jinghua Liu, Melanie J. Scott, Yuehua Li, Song Li, Wen Xie, Timothy R. Billiar, Mark A. Wilson, Yong Jiang, Ping Wang, and Jie Fan*. Cold-Inducible RNA-Binding Protein through TLR4 Signaling Induces Mitochondrial DNA Fragmentation and Regulates Macrophage Cell Death after Trauma. Cell Death & Disease. 2017 May 11;8(5):e2775.  doi:10.1038/cddis.2017.187
     
14. Zhigang Li, Melanie J. Scott, Tomasz Brzóska, Prithu Sundd, Yue-Hua Li, Timothy R. Billiar, Mark A. Wilson, Ping Wang, Jie Fan*. Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages. Military Medical Research. 2018 Jul 30;5(1):24. doi: 10.1186/s40779-018-0173-6.
15. Zhigang Li^#, Yang Jiao^#, Erica K. Fan, Melanie J. Scott, Yuehua Li, Song Li, Timothy R. Billiar, Mark A. Wilson, Xueyin Shi*, Jie Fan*. Aging-Impaired Filamentous Actin Polymerization Signaling Reduces Alveolar Macrophage Phagocytosis of Bacteria. Journal of Immunology. 2017 Nov 1;199(9):3176-3186.
16. Yang Jiao^#, Zhigang Li^#, Patricia A. Loughran, Erica K. Fan, Melanie J. Scott, Yuehua Li, Timothy R. Billiar, Mark A. Wilson, Xueyin Shi, and Jie Fan. Frontline Science: Macrophage-derived exosomes promote neutrophil necroptosis following hemorrhagic shock. Journal of Leukocyte Biology. 2018 Feb;103(2):175-183. (^#co-first author)

个人邮箱：

lizhg25@mail.sysu.edu.cn

本课题组欢迎分子医学、细胞生物、神经科学等相关专业的优秀硕博士加盟！