个人简介：

   贺浩哲，中山大学附属第七医院副研究员、硕士生导师。2020年6月博士毕业于中山大学，师从帅心涛教授。致力于生物医用高分子材料和纳米药物的开发与应用，在刺激响应性纳米递药载体的构建、纳米药物穿越生理屏障、肿瘤诊断与治疗等方面积累了丰富经验。以第一作者/通讯作者在Advanced Drug Delivery Reviews、Small、Journal of Controlled Release、Acta Biomaterialia、Science China-Chemistry、Chinese Chemical Letters等期刊发表论文10余篇，获授权中国发明专利3项。主持国家自然科学基金青年基金项目、广东省自然科学基金面上项目、广东省区域联合基金青年基金项目、深圳市自然科学基金面上项目等多项科研项目。

学习和工作经历：

2025.01－至今，中山大学附属第七医院，副研究员

2022.08－2024.12，中山大学附属第七医院，助理研究员

2020.08－2022.08，中山大学附属第七医院，博士后

2017.08－2020.06，中山大学材料科学与工程学院，博士

2015.07－2017.07，中国科学院长春应用化学研究所，项目聘用

2012.09－2015.06，河南大学化学化工学院，硕士

研究方向：

1、响应性纳米药物的构建与靶向输送

2、病灶微环境调控体系抑制病程进展的研究

代表性论文：

[1] Yeling Yuan^#, Lihua Du^#, Kejing Zeng^#, Yilu Zheng^#, Huaping Huang, Yu Shao, Wenqing Wang, Leping Yan, Jun Wu*, Changhua Zhang*, Hongman Xue*, Haozhe He*. Hyaluronic Acid-Modified MOF Nanoparticles for Encapsulating Asparaginase in T-Cell Acute Lymphoblastic Leukemia Treatment. Chinese Chemical Letters, 2025, 111222.

[2] Huaping Huang^#, Lihua Du^#, Rishun Su^#, Zhuoyuan Li, Yu Shao, Yeling Yuan, Chen Wang, Changzheng Lu, Yulong He*, Haozhe He*, Changhua Zhang*. Albumin-based co-loaded sonosensitizer and STING agonist nanodelivery system for enhanced sonodynamic and immune combination antitumor therapy. Journal of Controlled Release, 2024, 375, 524-536.

[3] Kejing Zeng^#, Haozhe He^#, Zhenjing Lv^#, Ming Lei, Weikun Wu, Hao Sun, Gordon GaaLam Wong, YatSze Sheila Kwok, Junzhang Tian*, and Gugen Xu*. Profiling of circulating serum exosomal microRNAs in elderly patients with infectious stress hyperglycaemia. Clinical and Translational Discovery, 2023, 3, e205.

[4] Haozhe He^#, Lihua Du^#, Hongman Xue^#, Yongcheng An, Kejing Zeng, Huaping Huang, Yulong He, Changhua Zhang*, Jun Wu*, and Xintao Shuai*. Triple Tumor Microenvironment‐Responsive Ferroptosis Pathways Induced by Manganese‐Based Imageable Nanoenzymes for Enhanced Breast Cancer Theranostics. Small Methods, 2023, 7, 2300230.

[5] Haozhe He^#, Lihua Du^#, Hongman Xue*, Jun Wu*, and Xintao Shuai*. Programmable Therapeutic Nanoscale Covalent Organic Framework for Photodynamic Therapy and Hypoxia-Activated Cascade Chemotherapy. Acta Biomaterialia, 2022, 149, 297-306.

[6] Haozhe He^#, Xindan Zhang^#, Lihua Du, Minwen Ye, Yonglai Lu, Jiajia Xue*, Jun Wu*, and Xintao Shuai*. Molecular imaging nanoprobes for theranostic applications. Advanced Drug Delivery Reviews, 2022, 186, 114320.

[7] Lihua Du^#, Haozhe He^#, Zecong Xiao, Hong Xiao, Yongcheng An, Huihai Zhong, Minzhao Lin, Xiaochun Meng, Shisong Han* and Xintao Shuai*. GSH-Responsive Metal-Organic Framework for Intratumoral Release of NO and IDO Inhibitor to Enhance Antitumor Immunotherapy. Small, 2022, 18, 2107732.

[8] Haozhe He, Lihua Du, Huanling Guo, Yongcheng An, Liejing Lu, Yali Chen, Yong Wang, Huihai Zhong, Jun Shen*, Jun Wu, and Xintao Shuai*. Redox Responsive Metal Organic Framework Nanoparticles Induces Ferroptosis for Cancer Therapy. Small, 2020, 16, 2001251.

[9] Haozhe He, Lihua Du, Min Tan, Yali Chen, Liejing Lu, Yongcheng An, Yong Wang, Xiaoxia Li, Bo Li, Jun Shen, Jun Wu, and Xintao Shuai*. Cleavable bimetallic-organic polymers for ROS mediated cascaded cancer therapy under the guidance of MRI through tumor hypoxia relief strategy. Science China-Chemistry, 2020, 63, 936-945.

[10] Haozhe He, Junli Zhou, Yingjie Liu, Shi Liu, Zhigang Xie*, Meng Yu, Yong Wang, and Xintao Shuai*. Near-infrared Light Induced Morphology Transition of Poly(ether amine) Nanoparticles for Supersensitive Drug Release. ACS Applied Materials & Interfaces, 2018, 10, 7413-7421.

[11] Haozhe He, Xiaohua Zheng, Shi Liu, Min Zheng*, Zhigang Xie*, Yong Wang, Meng Yu and Xintao Shuai*. Diketopyrrolopyrrole-based carbon dots for photodynamic therapy. Nanoscale, 2018, 10, 10991-10998.

[12] Haozhe He, Xiaohua Zheng, Jianxu Zhang, Shi Liu, Xiuli Hu and Zhigang Xie*. Photothermal induced accumulation and retention of polymeric nanoparticles in tumor for long-term fluorescent imaging. Journal of Materials Chemistry B, 2017, 5, 2491-2499.

[13] Haozhe He, Yanrong Ren*, Zhanfeng Wang and Zhigang Xie*. A pH-responsive poly(ether amine) micelle with hollow structure for controllable drug release. RSC Advances, 2016, 6, 91940-91948.

[14] Haozhe He, Yanrong Ren*, Yuge Dou, Tao Ding, Xiaomin Fang, Yuanqing Xu, Hao Xu, Wenkai Zhang and Zhigang Xie*. Photo-cross-linked poly(ether amine) micelles for controlled drug release. RSC Advances, 2015, 5, 105880-105888.

已授权专利：

1、帅心涛，贺浩哲，杜丽华。一种谷胱甘肽和过氧化氢敏感的锰基纳米颗粒及其制备方法和应用，专利号：ZL202210750642.8（2024年2月23日授权）。

2、帅心涛，杜丽华，贺浩哲，钟汇海，林敏钊。一种谷胱甘肽敏感的纳米载药系统及其制备方法和应用，专利号：ZL202111321721.9（2023年4月14日授权）。

3、任艳蓉，贺浩哲，王延鹏，刘保英，丁涛，房晓敏，徐元清，徐浩，张文凯。一种pH敏感光交联的聚乙二醇空心球、其制备方法及应用，专利号：ZL201610604268.5（2017年12月12日授权）。

个人邮箱：

hehzh8@mail.sysu.edu.cn