个人简介：
中山大学硕士生导师，副研究员，中山大学海外高层次引进人才，广东省精准医学应用学会精准检测分会常务委员。博士毕业于中山大学中山医学院病原生物学专业，曾任杜克大学医学院高级研究员。主要研究方向：肿瘤代谢免疫以及耐药的分子机制研究。主持省部级以上课题4项，出版学术专著1部（独立著作），获得广东省科学技术奖励二等奖1项。已申请美国PCT专利1项，中国发明专利4项（已授权2项）。累积发表SCI论文30余篇，包括Cell Metabolism，Nature Cell Biology，Cell Discovery， Molecular Cell，JOURNAL OF EXPERIMENTAL MEDICINE，STAR Protocols等学术期刊。
著作、论文、成果：
1. Che-Chia Hsu, Guihua Wang, Chien-Feng Li, XIAN ZHANG, Zhen Cai, Tingjin Chen, Bo-Syong Pan, Rajesh Kumar Manne, Gagan Deep, Haiwei Gui, Yuzhuo Wang, Danni Peng, Vasudevarao Penugurti, Xiaobo Zhou, Zhigang Xu, Zhong-zhu Chen, Ming Chen, Andrew Armstrong, Jiaoti Huang, Hong-yu Li, and Hui-Kuan Lin. IMPA1-derived inositol maintains stemness in castration resistant prostate cancer via IMPDH2 activation. J Exp Med. 2024 Nov 4;221(11):e20231832.
2. Chen T, Lin HK. Protocol to analyze the role of various metabolites in impacting global RNA 5-methylcytosine levels in cultured cells by dot blot. STAR Protocols 2024 Jan 4;5(1):102815.
3. Meng Bian, Shan Li, Hanzong Zhou, Lijun Bi, Yong Shen, Tingjin Chen, Xinbing Yu, Yan Huang, Qingxia Xu. ASPSCR-1 and Sirt-5 alleviate Clonorchis liver fluke rCsNOSIP-induced oxidative stress, proliferation, and migration in cholangiocarcinoma cells. PLoS Negl Trop Dis 17(11): e0011727.
4. Chen T, Xu ZG, Luo J, Manne RK, Wang Z, Hsu CC, Pan BS, Cai Z, Tsai PJ, Tsai YS, Chen ZZ, Li HY, Lin HK. NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance. Cell Metab. 2023 Aug 3:S1550-4131(23)00267-X.
5. Li S, Chen X, Zhou J, Xie Z, Shang M, He L, Liang P, Chen T, Mao Q, Liang C, Li X, Huang Y, Yu X. Amino acids serve as an important energy source for adult flukes of Clonorchis sinensis. PLoS Negl Trop Dis. 2020 Apr 30;14(4):e0008287.
6. Liu C, Ma Z, Cai Z, Zhang F, Liu C, Chen T, Peng D, Xu X, Lin HK. Identification of primordial germ cell-like cells as liver metastasis initiating cells in mouse tumour models. Cell Discov. 2020 Mar 24;6:15.
7. Hsu CC, Zhang X, Wang G, Zhang W, Cai Z, Pan BS, Gu H, Xu C, Jin G, Xu X,
Manne RK, Jin Y, Yan W, Shao J, Chen T, Lin E, Ketkar A, Eoff R, Xu ZG, Chen ZZ,
Li HY, Lin HK. Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK. Mol Cell. 2021 Sep 16;81(18):3803-3819.e7.
8. Kant R, Manne RK, Anas M, Penugurti V, Chen T, Pan BS, Hsu CC, Lin HK.
Deregulated transcription factors in cancer cell metabolisms and reprogramming.
Semin Cancer Biol. 2022 Nov;86(Pt 3):1158-1174.
9. Wang N, Zhang Z, Huang L, Chen T, Yu X, Huang Y. Current status and progress
in the omics of Clonorchis sinensis. Mol Biochem Parasitol. 2023 Apr 29;255:111573.
10. Chen T#, Jiang H#, Sun H, Xie Z, Ren P, Zhao L, Dong H, Shi M, Lv Z, Wu Z, Li X, Yu X, Huang Y, Xu J. Sequence analysis and characterization of pyruvate kinase
from Clonorchis sinensis, a 53.1-kDa homopentamer, implicated immune protective
efficacy against clonorchiasis. Parasit Vectors. 2017 Nov 9;10(1):557.
11. Tang Z#, Sun H#, Chen T#, Lin Z, Jiang H, Zhou X, Shi C, Pan H, Chang O, Ren P, Yu J, Li X, Xu J, Huang Y, Yu X. Oral delivery of Bacillus subtilis spores expressing cysteine protease of Clonorchis sinensis to grass carp (Ctenopharyngodon idellus): Induces immune responses and has no damage on liver and intestine function. Fish Shellfish Immunol. 2017 Mar 18;64:287-296.
12. Jiang H#, Chen T#, Sun H, Tang Z, Yu J, Lin Z, Ren P, Zhou X, Huang Y, Li X, Yu X. Immune response induced by oral delivery of Bacillus subtilis spores expressing enolase of Clonorchis sinensis in grass carps (Ctenopharyngodon idellus). Fish and Shellfish Immunology. 2017 Jan;60:318-325.
13. Chen W#, Ning D#, Wang X#, Chen T#, Lv X, Sun J, Wu D, Huang Y, Xu J, Yu X. Identification and characterization of Clonorchis sinensis cathepsin B proteases in the pathogenesis of clonorchiasis. Parasit Vectors. 2015 Dec 21;8(1):647.
14. Yu J#, Chen T#, Xie Z, Liang P, Qu H, Shang M, Mao Q, Ning D, Tang Z, Shi M, Zhou L, Huang Y, Yu X. Oral delivery of Bacillus subtilis spore expressing enolase of Clonorchis sinensis in rat model: induce systemic and local mucosal immune responses and has no side effect on liver function. Parasitol Res. 2015 Jul;114(7):2499-505.
15. Chen T#, Yu J#, Tang Z, Xie Z, Lin Z, Sun H, Wan S, Li X, Huang Y, Yu X, Xu J. Advanced Enzymology, Expression Profile and Immune Response of Clonorchis sinensis Hexokinase Shows Its Application Potential for Prevention and Control of Clonorchiasis. PLoS Negl Trop Dis. 2015 Mar 23;9(3):e0003641.
16. Chen T, Ning D, Sun H, Li R, Shang M, Li X, Wang X, Chen W, Liang C, Li W, Mao Q, Li Y, Deng C, Wang L, Wu Z, Huang Y, Xu J, Yu X. Sequence analysis and molecular characterization of Clonorchis sinensis hexokinase, an unusual trimeric 50-kDa glucose-6-phosphate-sensitive allosteric enzyme. PLoS ONE 9(9): e107940.
17. Chen T, Huang Y, Yu X. Serious challenge and thinking of clonorchiasis. Chin J Dis Control Prev. 2016,20(1):1-4,12. (in Chinese)
18. Chen T, Yu X. Pregnancy with listeria infection. Chin J Obstet Emerg. 2015 May,4(2):105-109. (in Chinese)
19. Tang Z#, Shang M#, Chen T, Ren P, Sun H, Qu H, Lin Z, Zhou L, Yu J, Jiang H, Zhou X, Li X, Huang Y, Xu J, Yu X. The immunological characteristics and probiotic function of recombinant Bacillus subtilis spore expressing Clonorchis sinensis cysteine protease. Parasit Vectors. 2016 Dec 19;9(1):648.
20. Li W#, Dong H#, Huang Y, Chen T, Kong X, Sun H, Yu X, Xu J. Clonorchis sinensis Co-infection Could Affect the Disease State and Treatment Response of HBV Patients. PLoS Negl Trop Dis. 2016 Jun 27;10(6):e0004806.
21. Zhou L, Shi M, Zhao L, Lin Z, Tang Z, Sun H, Chen T, Lv Z, Xu J, Huang Y, Yu
X. Clonorchis sinensis lysophospholipase A upregulates IL-25 expression in macrophages as a potential pathway to liver fibrosis. Parasit Vectors. 2017 Jun 17;10(1):295.
22. Shi M, Zhou L, Zhao L, Shang M, He T, Tang Z, Sun H, Ren P, Lin Z, Chen T, Yu
J, Xu J, Yu X, Huang Y. Csseverin inhibits apoptosis through mitochondria-mediated pathways triggered by Ca2+ dyshomeostasis in hepatocarcinoma PLC cells. PLoS Negl Trop Dis. 2017 Nov 10;11(11):e0006074.
23. Jia F, Li Y, Huang Y, Chen T, Li S, Xu Y, Wu Z, Li X, Yu X. Molecular characterization and expression of Rab7 from Clonorchis sinensis and its potential role in autophagy. Parasitol Res. 2013 Jul;112(7):2461-7.
24. Xu J, Wang L, Deng C, Hu X, Li R, Chen T, Ning D, Wu Y, Huang Y, Li X, Wu Z, Yu X, Li Y. The serological diagnosis of human clonorchiasis by time-resolved fluoroimmunoassay based on GST2-specific IgG4 detection. Parasitol Res. 2014 Jan;113(1):149-55.
25. Ren M, He L, Huang Y, Mao Q, Li S, Qu H, Bian M, Liang P, Chen X, Ling J, Chen T, Liang C, Wang X, Li X, Yu X. Molecular characterization of Clonorchis sinensis secretory myoglobin: Delineating its role in anti-oxidative survival. Parasit Vectors. 2014 May 29;7:250.
26. Mao Q, Xie Z, Wang X, Chen W, Ren M, Shang M, Lei H, Tian Y, Li S, Liang P, Chen T, Liang C, Xu J, Li X, Huang Y, Yu X. Clonorchis sinensis ferritin heavy chain triggers free radicals and mediates inflammation signaling in human hepatic stellate cells. Parasitol Res. 2015 Feb;114(2):659-70.
27. Zhou L, Shang M, Shi M, Zhao L, Lin Z, Chen T, Wu Y, Tang Z, Sun H, Yu J, Huang Y, Yu X. Clonorchis sinensis lysophospholipase inhibits TGF-β1-induced expression of pro-fibrogenic genes through attenuating the activations of Smad3, JNK2, and ERK1/2 in hepatic stellate cell line LX-2. Parasitol Res. Parasitol Res. 2016 Feb;115(2):643-50. doi: 10.1007/s00436-015-4782-7.
28. Wu Y, Li Y, Shang M, Jian Y, Wang C, Bardeesi AS, Li Z, Chen T, Zhao L, Zhou L, He A, Huang Y, Lv Z, Yu X, Li X. Secreted phospholipase A2 of Clonorchis sinensis activates hepatic stellate cells through a pathway involving JNK signalling. Parasit Vectors. 2017 Mar 16;10(1):147.
29. Wu Z, Tang Z, Shang M, Zhao L, Zhou L, Kong X, Lin Z, Sun H, Chen T, Xu J, Li X, Huang Y, Yu X. Comparative analysis of immune effects in mice model: Clonorchis sinensis cysteine protease generated from recombinant Escherichia coli and Bacillus subtilis spores. Parasitol Res. 2017 Jul;116(7):1811-1822.
30. Wang C, Lei H, Tian Y, Shang M, Wu Y, Li Y, Zhao L, Shi M, Tang X, Chen T, Lv Z, Huang Y, Tang X, Yu X, Li X. Clonorchis sinensis granulin: identification, immunolocalization, and function in promoting the metastasis of cholangiocarcinoma and hepatocellular carcinoma. Parasit Vectors. 2017 May 25;10(1):262.
31. Zhao L, Shi M, Zhou L, Sun H, Zhang X, He L, Tang Z, Wang C, Wu Y, Chen T, Shang M, Zhou X, Lin Z, Li X, Yu X, Huang Y. Clonorchis sinensis adult-derived proteins elicit Th2 immune responses by regulating dendritic cells via mannose receptor. PLoS Negl Trop Dis. 2018 Mar 5;12(3):e0006251.
32. Sun H, Lin Z, Zhao L, Chen T, Shang M, Jiang H, Tang Z, Zhou X, Shi M, Zhou L, Ren P, Qu H, Lin J, Li X, Xu J, Huang Y, Yu X. Bacillus subtilis spore with surface display of paramyosin from Clonorchis sinensis potentializes a promising oral vaccine candidate. Parasit Vectors. 2018 Mar 7;11(1):156.
33. 任鹏丽,陈庭金,黄艳,曾伟伟,余新炳. 草鱼呼肠孤病毒HZ08株外衣壳蛋白VP4的节段克隆表达和免疫学分析[J]. 热带医学杂志,2016,02:140-144+271.
34. 石梦辰,陈庭金,周丽娜,赵璐,任鹏丽,孙恒昌,林志鹏,黄艳,余新炳. 华支睾吸虫severin蛋白对肝癌细胞SMMC-7402增殖、迁移及侵袭作用的初步研究[J]. 热带医学杂志,2016,02:127-130+205+272.
35. 杨旭然,陈庭金,余新炳. 诱导型一氧化氮合酶与寄生虫感染的研究进展[J]. 中国病原生物学杂志, 2016,09:855-857.
36. 侯珠秀,陈庭金,黄艳,余新炳. IL-25在寄生虫感染性疾病中的研究进展[J]. 热带医学杂志,2016,08:1086-1088.
37. 宛硕,黄艳,陈庭金,徐劲,余新炳. 巨噬细胞极化的研究进展[J]. 中国病原生物学杂志,2015,11:1051-1054.
38. 李然,余新炳,陈庭金,邓传欢,王乐旬,李文芳,黄艳,徐劲. 华支睾吸虫钙调理蛋白的克隆表达、组织定位及功能的初步研究[J]. 中国病原生物学杂志,2013,05:411-416.
39. 孙恒昌,陈庭金,黄艳,徐劲,余新炳. 鱼用疫苗研究进展[J]. 热带医学杂志,2014,12:1651-1656.
40. 陈志文,冯姣,蒋敏敏,陈春梅,肖星,何娅,易修文,陈庭金,席丽艳. 构建以eGFP为报告基因的毕赤酵母表达载体[J]. 皮肤性病诊疗学杂志,2016,03:152-155.
41. 王彩琴,雷华丽,田艳丽,尚梅,吴银娟,李晔,陈庭金,黄艳,余新炳,李学荣. 华支睾吸虫颗粒蛋白在虫体及宿主中的表达[J]. 热带医学杂志,2017,(04):413-415+434+408.
专利:
1. INHIBITION OF NSUN2 FOR THE TREATMENT OF CANCER，申请时间2023年7月14日，Hui-Kuan Lin,Tingjin Chen，美国，专利申请号: 63/513,693.
2. 余新炳,周心怡,姜红烨,唐泽丽,孙恒昌,黄艳,陈庭金,林志鹏,任鹏丽. 通用型淡水鱼多克隆抗体及其制备与应用[P]. 广东：CN106565842A,2017-04-19.
3. 余新炳,任鹏丽,黄艳,陈庭金,唐泽丽,孙恒昌,林志鹏,姜红烨,周心怡. 一种草鱼出血病口服疫苗及其制备与应用[P]. 广东：CN105801707B, 2019-08-30.
4. 余新炳,孙恒昌,姜红烨,周心怡,唐泽丽,林志鹏,黄艳,陈庭金. 一种淡水鱼华支睾吸虫囊蚴感染胶体金快速检测试纸条及其制作方法[P]. 广东：CN106771171A,2017-05-31.
5. 余新炳,唐泽丽,孙恒昌,姜红烨,黄艳,陈庭金,林志鹏,周心怡. 鱼华支睾吸虫病口服疫苗及其制备与应用[P]. 广东：CN107266578B, 2021-05-07.
专著:
陈庭金.华支睾吸虫糖酵解关键酶己糖激酶的功能研究[M].北京：《中国学术期刊（光盘版）》电子杂志社有限公司,2024.（ISBN:978-7-499-01189-2, 入选“十三五”国家重点出版规划项目——青年学者优秀学术专著文库）
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