个人简介：
课题组长期围绕细胞自噬与线粒体自噬调控、程序性细胞死亡及其在肿瘤和相关疾病中的应用开展研究。近年来以第一作者或通讯作者（共同）在 Lancet Microbe、Med、Signal Transduction and Targeted Therapy、Autophagy、Acta Pharmaceutica Sinica B、Journal of Biological Chemistry 等期刊发表SCI论文20篇，其中近五年发表13篇，论文被他引800余次。主持国家自然科学基金青年项目、广东省前沿与关键技术创新专项粤港联合创新项目及深圳市科技创新委员会面上项目等，已获授权中国发明专利、美国专利和欧洲专利各1项，并于2016年获得深圳市科技创新委员会颁发的省级科技项目奖。
研究方向：细胞自噬，线粒体自噬，线粒体质量控制与肿瘤代谢。早前通过高通量筛选发现新型、低毒、可逆的自噬及内体途径抑制剂vacuolin-1；进一步揭示和厚朴酚诱导的PINK1-Parkin依赖性线粒体自噬具有肿瘤细胞保护作用，提出联合抑制自噬/线粒体自噬以增强抗肿瘤疗效的策略。在此基础上，阐明PINK1抑制可通过放大线粒体ROS信号、促进TOMM20氧化寡聚化及激活BAX-caspase-3-GSDME通路，诱导神经母细胞瘤焦亡。同时，围绕环境复合暴露与肿瘤免疫治疗，揭示镉与百草枯协同诱发帕金森样神经损伤的线粒体机制，并参与构建锰-阿仑膦酸免疫放大纳米药物，为结直肠癌腹膜转移治疗提供新思路。此外，课题组还开展了新冠康复及疫苗接种免疫研究，提出联合治疗、异源接种及个体化免疫方案。
主要代表性论著：(# equal contribution, * Corresponding author)
- Lu Y.Y.#, Zhu Y#, Cui M, Cheng Z, Hong P*. Post-recovery enhancement of anti-variant neutralisation after severe COVID-19. Lancet Microbe. 2022. 3(5):e330-e331. 柳叶刀子刊 中科院一区IF：21.9
- Zhu Y#, Lu Y.Y.#, Tang L, Zhou C, Liang R, Cui M, Xu Y, Zheng Z, Cheng Z, Hong P*. Finite neutralisation breadth of omicron after repeated vaccination. Lancet Microbe. 2022. 3(10):e729. 柳叶刀子刊 中科院一区 IF：21.9 月度热点论文第二名
- Zhu Y#, Lu Y.Y.#, Zhou C#, Tong G#, Gao M#, Zhan Y#, Wang Y#, Liang R, Li Y, Gao T, Wang L, Zhang M, Cheng J, Gong J, Wang J, Zhang W, Qi J, Cui M, Zhu L, Xiao F, Zhu L, Xu Y, Zheng Z, Zhou Z*, Cheng Z*, Hong P*. Association of neutralizing breadth against SARS-CoV-2 with inoculation orders of heterologous prime-boost vaccines. Med. 2022. 3(8):568-578.e3. Cell子刊 中科院一区 IF：13.3 该论文被选为当期的Featured Content
- Lu Y.Y.#, Liu F.#, Tong G.L.#, Qiu F., Song P. H., Wang X.L., Zou X.F., Wan D.Y., Cui M., Xu Y.S., Zheng Z.H., Hong P*. Clinical evidence of an interferon–glucocorticoid therapeutic synergy in COVID-19. Signal Transduction and Targeted Therapy. 2021. 6(1):107. 中科院一区 IF：81.2
- Zhu Y#, Cao M#, Tang Y#, Liu Y, Wang H, Huang C, Yan C, Liu X, Jiang S, Luo Y, Qi J, Wang S, Xu H*, Lu Y.Y.*, Wang L*. Inhibition of PINK1 senses ROS signaling to facilitate neuroblastoma cell pyroptosis. Autophagy. 2025. 21(10): 2091-2110. 中科院一区 IF: 18.6
- Lu Y.Y., Dong S, Hao B, Li C, Zhu K, Guo W, Wang Q, Cheung KH, Wong CW, Wu WT, Markus H, Yue J*. Vacuolin-1 Potently and Reversibly Inhibits Autophagosome-Lysosome Fusion by Activating RAB5. Autophagy. 2014.10: 1-12. 中科院一区 IF: 18.6
- Xu P#, Ye Z#, Zhu Y, Chan C, Li Y, Huang H, Zhu C, Zhang X, Wang Y, Lin N, Sun W, Peng M, Lu Y.Y.*, Yue J*. CAPZ regulates endosomal–exosomal trafficking of plasma membrane PD-L1 independently of canonical autophagy. Journal of Biological Chemistry. 2026 Sep 29:113612. doi: 10.1016/j.jbc.2026.113612. Online ahead of print.
- Tang Y.C.# , Wang L.M.# , Yi T., Xu J., Wang J.Q., Qin J.J., Chen Q.L., Yip K.M., Pan Y.H., Hong P., Lu Y.Y.*, Shen H.M.*, Chen H.B.* Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacy. Acta Pharmaceutica Sinica B. 2021. 11(12):3966-3982. 中科院一区 IF：14.6
- Qiu M#, Wen Y#, Fang S, Hao T, Xu H, Deng X, Yamakawa T, Li B, Zhang S, Lu Y.Y.*, Zhang C*, Zhao J*.Engineering manganese-based immune amplifier for chemoimmunotherapy of peritoneal metastatic colorectal cancer. Materials Today Bio. 2026. 39:103376. doi: 10.1016/j.mtbio.2026.103376. 中科院一区IF：11
- Luo, Y#., Lu Y.Y.#., Tang, Y#., Zhao, X., Wang, J., Liu, Y., Jiang, S., Zhu, Y., Qi, J., Xing, L., Yan, C., Liu, X., Huang, C., Wang, H., Xu, H., Wang, L*. Synergistic Neurotoxicity of environmental Cadmium and Paraquat in Parkinsonism: Unveiling the Mito-ROS/OPA1/Caspase-3/GSDME-driven Apoptosis Axis. Int. J. Biol. Sci. 2026. 22(6): 2885-2905. 中科院一区IF：11.7
- Zhu Y#, Lu Y.Y.#, Lu AL#, Zhou C, Kebocuo, Hong P*. Persistent vaccine-elicited humoral immune imprinting in Tibetans: a matched cohort study in Tibet. Clinical Microbiology And Infection. 2025. 31(3):475-476. 中科院一区IF: 8.7
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Lu Y.Y., Chen T.S., Qu J.L., Pan W.L., et al. Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma cells. J. Biomed. Sci. 2010. 16: 1-16. 中科院一区 IF: 14.5
个人邮箱：
luyy39@sysu.edu.cn